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Institut Pasteur

The Institut Pasteur is a recognized charitable foundation that is authorized to receive donations and legacies, established by Louis Pasteur in 1887. It is also an internationally renowned center for biomedical research and part of the Pasteur Network of 33 members operating in 25 countries on five continents worldwide. Since July 1, 2021, the Institut Pasteur has been a partner research organization of Université Paris Cité.

Crédit : © Institut Pasteur / Thomas LANG

The Institut Pasteur’s mission is to tackle diseases in France and throughout the world, through initiatives in four main areas: research, public health, training, and development of research applications. It is a globally recognized leader in infectious diseases, microbiology, and immunology, with research focusing on the biology of living systems. Among its areas of research are emerging infectious diseases, antimicrobial resistance, cancer, neurodegenerative diseases, and brain connectivity disorders. The Institut Pasteur’s outstanding research is facilitated by the development of a technological environment of the highest standard, with core facilities for nanoimaging, computational biology and artificial intelligence.

The aim of the partnership established with Université Paris Cité is to build a concerted joint scientific strategy based on the consolidation and co-development of existing themes addressed by the two institutions, both in fundamental and translational research as well as in education.

The Institut Pasteur functions as a partner research organization of Université Paris Cité, which constitutes a guarantee of institutional, scientific and financial independence for the two partners within a balanced governance structure.

Both institutions have recognized expertise in the field of infectious diseases. Numerous collaborations already exist between Université Paris Cité and the Institut Pasteur in research and training, and the sharing of human and technological resources and expertise will further strengthen the ties between the two partners.

The partnership will facilitate mobility opportunities for researchers and students, implementation of new technological platforms and the emergence of new research structures.

Moreover, interdisciplinary approaches to global health issues may be pursued. These developments will serve to expand the reach of the two institutions as they accomplish their missions.

Visit the Institut Pasteur website

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Theileria annulata and Cancer: a parasite strategy revealed!

A new study from Prof. Jonathan Weitzman’s research team at the Epigenetics and Cell Fate unit has shed light on the mechanism by which the parasite Theileria annulata, which causes a cancer-like diseases in cattle, evades the host cell’s defense mechanism.

Theileria annulata et Cancer : une stratégie du parasite dévoilée !

Recherche Santé

L’équipe de recherche du Pr Jonathan Weitzman a mis en lumière le mécanisme par lequel le parasite Theileria annulata, responsable de maladies semblables aux cancers chez les bovins, échappe au mécanisme de défense de la cellule hôte.

Université Paris Cité félicite le professeur Anton Zorich pour l’obtention de son ERC Advanced Grant

ERC Advanced Grant 2023 : le professeur Anton Zorich, mathématicien à l’université Paris Cité compte parmi les 37 lauréates et lauréats français.

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News | 2023.01.18

A journey into the diversity of people with autism

With his book Des gènes, des synapses, des autismes: Un voyage vers la diversité des personnes autistes (French Edition), Thomas Bourgeron and his team delve into DNA in a fascinating investigation in search of the genes associated with autism (or rather the diversity of people with autism).

Article | 2024.02.01

Bourses de la Fondation Pierre Ledoux Jeunesse Internationale

Bourses cofinancées par la Fondation Pierre Ledoux Jeunesse Internationale (séjour) et la Direction Internationale de l'Institut Pasteur (voyage) pour effectuer un stage dans les laboratoires d'un institut du Pasteur Network dans un pays en développement. 

News | 2020.02.27

Foreign travel – a tonic for the health?

All travelers can come into contact with health risks that are completely different from those they generally encounter on a daily basis. So it is vital to prepare thoroughly for any trip – and that involves consulting a specialist travel clinic such as the Institut Pasteur Medical Center (CMIP).Travel is a formative experience for young people – and young people often take a casual attitude to...

News | 2019.09.27

Rabies: a shorter, cheaper vaccination schedule following a suspected rabid dog bite

 A study by teams from the Institut Pasteur du Cambodge and the Institut Pasteur in Paris confirms the efficacy of the new post-exposure rabies vaccination schedule developed in the Institut Pasteur International Network and adopted by the World Health Organization (WHO). Since 2018, WHO has recommended post-exposure vaccination for rabies, immediately after a bite by a suspected rabid...

Document de presse | 2021.04.14

Genetic admixture in the South Pacific: from Denisovans to the human immune response

Describing the genetic diversity of human populations is essential to improve our understanding of human diseases and their geographical distribution. However, the vast majority of genetic studies have been focused on populations of European ancestry, which represent only 16% of the global population. Scientists at the Institut Pasteur, Collège de France, and CNRS have looked at understudied...

Document de presse | 2023.03.29

World Autism Awareness Day: Institut Pasteur working actively with clinicians and the autism community

As we mark World Autism Awareness Day on Sunday April 2, 2023, this year the Institut Pasteur is celebrating the 20th anniversary of the discovery of the first genes associated with autism. In 2003, this discovery offered a new perspective on the neurodevelopmental disorder; today, it highlights what still needs to be done to help those affected by autism. Scientists in international consortia...

EXCLUSIVE In boost for Africa, Senegal aims to make COVID shots next year

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Additional reporting by Promit Mukherjee in Johannesburg, Wendell Roelf in Cape Town, Maggie Fick in Nairobi, Francesco Guerascio in Brussels and Nellie Peyton in Dakar Editing by Joe Bavier and Jane Merriman

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The U.S. on Tuesday imposed sanctions on leaders of militant groups over the taking of hostages, including Americans, in West Africa, the Treasury and State departments said.

Twenty one migrants died and another 23 are missing after a boat carrying 77 people capsized off the coast of Djibouti, the second such incident in two weeks, the United Nations migration agency said on Tuesday.

Egypt's economy will grow slower than previously expected this year after it signed an $8 billion financial support package with the IMF that came with conditions, but growth will accelerate next year, a Reuters poll forecast on Tuesday.

World Chevron

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The first witness in Donald Trump's criminal hush money trial, former National Enquirer publisher David Pecker, testified on Tuesday that he used his supermarket tabloid to suppress stories that might have hurt Trump's 2016 presidential bid.

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Institut Pasteur

International projects.

PvSTATEM: Serological testing & treatment of vivax malaria

Malaria elimination requires elimination of all malaria species. Although there has been tremendous progress in the development of new interventions for P. falciparum malaria, the goal of malaria elimination cannot be considered achievable unless […]

(SOCSET) Studying Olfactory and Cognitive Symptoms Evolution in long-COVID Patients

Sudden loss of smell is a common symptom associated with COVID-19 and SARS-CoV-2 infection of neurons in the olfactory system has been reported in both hamsters and humans. The vast majority of patients with […]

Myosins-Usher2 proteins complexes in hearing loss

The Usher syndrome (USH) is the main genetic disorder characterized by congenital hearing loss associated with progressive visual impairment. In the healthy person, each cochlear sensory cell from the inner ear presents hair bundles […]

SPHINx (Spread of Pathogens on Healthcare Institutions Networks)

Healthcare-associated infections (HAI) have been occurring with increased incidence and severity over the last decades, becoming a major public health issue. A wide range of control strategies is already available, including hygiene measures, barrier […]

International workshops on rabies diagnosis

Various workshops on the diagnosis of rabies are regularly organized at international level, in the form of theoretical courses and practical work sessions. These workshops are organized in close collaboration with local partners and […]

SHERLOCK4HAT

SHERLOCK4HAT African trypanosomes are transmitted by the bite of the tsetse fly and cause the debilitating, and often fatal, neglected tropical disease sleeping sickness, or Human African Trypanosomiasis (HAT). Trypanosoma brucei gambiense, the parasites […]

International Mixed Unit ‘Inflammation and Leishmania infection’ (IMU-InflaLeish): Exploiting host-pathogen interaction for the discovery of novel anti-microbial drug targets and drug candidates.

Recipient: Gerald Spaeth, PI Agency: Pasteur Institute, Type: Collaborative grant, 01/2016 – 12/2019 Based on ongoing collaborative actions we propose the creation of an IMU between three teams at IP Paris (G. Spaeth), IP […]

“Modelling and functional analysis of clonal Evolution in Leishmania – possible role of non-coding RNAs and RNA modification”

Recipient: Gerald Spaeth, coordinator Agency: Campus France, MEAE, Type: Bi-national program France/Israel, 04/2018 – 03/2020  Leishmaniasis is among the five most serious parasitic diseases worldwide. The cutaneous form of the disease is prevalent in […]

Plasmodium vivax Invasion Pathways into Human Reticulocytes

Erythrocyte invasion is a complex process involving multiple interactions between Plasmodium merozoites and host erythrocytes. Unlike P. falciparum, which can use multiple erythrocyte receptors for invasion and has merozoite proteins with overlapping and redundant […]

[Version française]… Cocaine addiction (CocAdd) is a major public health issue affecting 3% of the worlwide population, without validated pharmacotherapy. Nicotinic acetylcholine receptors (nAChRs)have been repeatedly associated in Human and rodent response to cocaine. […]

Risk of reemergence of urban yellow fever in Brazil: role of the invasive mosquito Aedes albopictus

2016 – 2018         Programmes Transversaux de Recherche Risk of reemergence of urban yellow fever in Brazil: role of the invasive mosquito Aedes albopictus PI: Ricardo Lourenço-de-Oliveira (Instituto de Oswaldo Cruz, Rio de Janeiro, Brazil)

Endocytosis: the clathrin-independent uptake of cytokine receptors

Endocytosis is an essential process used to internalize a wide range of molecules, and involved in many processes such as cell migration, cell division, immunity and pathogen invasion. Several endocytic pathways exist, enabling the […]

PP2A1 is a target for Alzheimer disease

  PP2A1 is the Tau phosphatase that can inactivate the specific neurodegenerative pathways resulting from hyperphosphorylation of the neuronal Tau protein. In collaboration with JH Colle (Institut Pasteur) we will analyze the effect of […]

PP2A a key target for viruses

We recently proposed that specific targeting of PP2A holoenzymes by viral proteins is a general biological strategy, used by various viruses (from DNA tumour viruses to HIV-1) to specifically deregulate intracellular pathways of their […]

The trimeric ABαC phosphatase named PP2A1 is a target for cancer therapy

Constitutive activity of the PI3K-Akt pathway is often associated with resistance to cancer therapies. Importantly PP2A1 is the Akt phosphatase that can inactivate this survival pathway associated with cancer progression. In this regard in […]

NéoVac (Neonatal Vaccination against Hepatitis B in Africa)

Chronic infection with hepatitis B virus (HBV) is an important cause of premature adult deaths in sub-Saharan Africa (SSA), due to liver cancer or cirrhosis. To reduce the disease burden, it is critical to […]

Regulation of retroviral infections

ERC-2015-StG RNAEPIGEN – Mechanisms of epigenetic inheritance by short RNAs

Epigenetic mechanisms are considered to be central to the development of multicellular organisms made of different cell types, all having identical genomes. Similarly, they may explain how genetically identical organisms are capable of adapting […]

Upstream stimulating factors USF1 and USF2 in the host response to Helicobacter pylori infection : impact on gastric carcinogenesis

The usptream stimulating factors USF1 and USF2 are pleïotropic transcription factors belong to the bHLH-Zip family as  the oncogene c-Myc. They act as homo- or heterodimers and interact with DNA consensus E-box sequences in […]

Impact of the host on microbial individuality

A deeper understanding of mycobacterial individuality entails looking at this phenomenon in the fluctuating host environment. Micro-fabrication of host-mimicking platforms (either cell- or tissue-based) by standard photolithography or 3D-printing techniques could allow us to […]

Molecular markers for cell quiescence

Fluorescent live cell imaging and single-cell analysis provide a clear glimpse into bacterial individuality. Discrete subpopulations can be separated either by conventional FACS or droplet sorting, and enriched subsets can be subjected to global […]

Single-cell gene expression dynamics

One of the significant drivers of phenotypic heterogeneity is noise in gene expression, which in turn is greatly influenced by fluctuations in the number of RNA molecules. Subcellular visualization of RNA turnover and quality […]

Alerting and Surveillance for Infectious Disease Epidemics

In a context of increasing globalization of trade, the growth in international flows of travelers and goods fuels the spread of infectious diseases. The need for a global alert and response network for infectious diseases […]

MediLabSecure

Preventing vector-borne diseases around the mediterranean and black sea regions by creating a One Health network of laboratories Countries of the Mediterranean and Black Sea regions share common public health issues and threats.  The MediLabSecure […]

PostDoc with expertise in Computational Biology/Bioinformatics

We are looking for a computational biologist/bioinformatician at the postdoc/research assistant level to join the ERC Synergy project DecoLeishRN (https://cordis.europa.eu/project/id/101071613). The successful candidate will join and collaborate with a vibrant, international team that applies […]

InferenceMAP

InferenceMAP  is a software aimed at analysing single molecule dynamics. InferenceMAP is based on Bayesian analysis of Random Walks and this version is focused on mapping Random Walks at the full cell scale in […]

Flemmingsome- A Midbody Remnant Proteome database

Cytokinesis leads to the physical separation of daughter cells and concludes cell division. Final abscission occurs close to the midbody (or Flemming body), a prominent structure that matures at the center of the intercellular […]

Publications

• 2024 Yamaguchi K, Chen X, Rodgers B, Miura F, Bashtrykov P, Bonhomme F, Salinas-Luypaert C, Haxholli D, Gutekunst N, Aygenli BÖ, Ferry L, Kirsh O, Laisné M, Scelfo A, Ugur E, Arimondo PB, Leonhardt H, Kanemaki MT, Bartke T, Fachinetti D, Jeltsch A, Ito T, Defossez , Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells, Nature communication.
• 2024 Tshepiso Mbangiwa, PhD Aude Sturny-Leclère, MSc Kwana Lechiile, MSc Cheusisime Kajanga, MSc Timothée Boyer-Chammard, MD Jennifer C Hoving, PhD , Development and validation of quantitative PCR assays for HIV-associated cryptococcal meningitis in sub-Saharan Africa: a diagnostic accuracy study, The Lancet Microbe.
• 2024 Koh C, Saleh MC, Mosquito core viromes: do they exist?, Trends Parasitol 2024 Jan; (): .
• 2024 Lise Hunault, Patrick England, Frédéric Barbut, Bruno Iannascoli, Ophélie Godon, François Déjardin, Christophe Thomas, Bruno Dupuy, Chunguang Guo, Lynn Macdonald, Guy Gorochov, Delphine Sterlin and Pierre Bruhns, A monoclonal antibody collection for C. difficile typing ?, .
• 2023 Grais RF, Sall AA, Cole ST, Science knows no country: fulfilling Louis Pasteur’s legacy., Lancet 2023 Dec; 400(10369): 2163-2164.
• 2023 Sebastian Duchene, Tracing the origin of virulence, Sciences.
• 2023 Koh C, Saleh MC, Translating mosquito viromes into vector management strategies., Trends Parasitol. 2023 Dec; 40(1):10-20 .
• 2023 Volle R, Luo L, Razafindratsimandresy R, Sadeuh-Mba SA, Gouandjika-Valisache I, Horwood P, Duong V, Buchy P, Joffret ML, Huang Z, Duizer E, Martin J, Chakrabarti LA, Dussart P, Jouvenet N, Delpeyroux F, Bessaud M, Neutralization of African enterovirus A71 genogroups by antibodies to canonical genogroups., J Gen Virol 2023 Nov; 104(11): .
• 2023 Mattern C, Pourette D, Andriamandimby SF, Rabarison J, Darsot A, Ralaizara B, Vray M, Shimakawa Y, Giles-Vernick T, Enjeux et difficultés de l’accès aux traitements pour la prise en charge de l’hépatite B chronique à Madagascar : étude qualitative auprès des soignants et personnes atteintes, Rev Epidemiol Sante Publique 2023 Jun; 71(4): 102088.
• 2022 Nicolas Puchot, Marie-Therèse Lecoq, Romuald Carinci, Jean Bernard Duchemin, Mathilde Gendrin and Catherine Bourgouin, Establishment of a colony of Anopheles darlingi from French Guiana for vector competence studies on malaria transmission, Front. Trop. Dis. 3:949300..
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Location: 25-28, rue du Dr Roux 75724 Paris, France

Institut Pasteur’s International Network

Institut pasteur’s international network.

Since its founding in 1891 with the establishment of its first Network site in Saigon, the Institut Pasteur International Network continues to advance discovery by bringing together 32 sites on 5 continents, united by shared missions, culture, and values. Click on the thumbnails below to view images of these 32 research sites.

Institut Pasteur, Paris

Institut Pasteur, Shanghai

Institut Pasteur, Rio-de-Janeiro

Institut Pasteur, Korea

Institut Pasteur, Guadeloupe

Institut Pasteur

Institut Pasteur, de Bangui

Institut Pasteur, De Montevideo

Institut Pasteur, D'Algerie

Institut Pasteur, Caledonia

Institut Pasteur, Cambodia

Institut Pasteur, Saigon

Pasteur Institute International Locations

Institut Pasteur, Vien

Institut Pasteur, Morocco

Institut Pasteur, Madagascar

Institut Pasteur, St. Petersburg

Institut Pasteur, Hong Kong

Institut Pasteur, deCote-D-Ivoire

Institut Pasteur, De La Guyane

Institut Pasteur, Bulgaria

Institut Pasteur Japan Innovation Center

Join us at our events, news & information.

Institut Pasteur de la Guadeloupe

Créé en 1948, l’Institut Pasteur de la Guadeloupe a tout d’abord consacré sa recherche à la lèpre et la bilharziose jusqu’à la fin des années 70, puis à la tuberculose en 1993 et au renforcement des activités en hygiène de l’environnement à la fin des années 90. A compter de 2011, l’IPG a créé une unité Environnement-santé. Aujourd’hui, il n’y a plus qu’une unité de recherche “transmission, réservoirs et diversité des pathogènes”.

L’Institut Pasteur de Guadeloupe emploie une cinquantaine de personnes dont 10 cadres scientifiques. Les activités actuelles concernent la recherche, la formation, la santé publique ainsi que les services tels que les vaccinations, le Laboratoire d’Hygiène de l’Environnement (LHE)et d’analyses médicales spécialisées.

Parmi les axes de recherche stratégiques de l’IPG :

• la recherche de méthodes alternatives aux insecticides pour le contrôle vectoriel.
• la compréhension des mécanismes d’échanges de gènes de résistance aux antibiotiques entre les différents biotopes humain, animal et environnemental pour mieux comprendre les risques liés à la diffusion environnementale de la résistance aux antibiotiques.
• la compréhension des réservoirs, des modes de transmission et la diversité génétique de certains pathogènes tels que les amibes libres, Salmonella, Klebsiella, Angiostrongylus et Mycobacterium tuberculoses.

Pour plus d’information, visitez le site officiel de l’ Institut Pasteur de la Guadeloupe .

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The Institut Pasteur du Cambodge is a Cambodian non-profit research institution. Operating under the high patronage of the Cambodian Ministry of Health its status and operation are governed by an agreement between the Royal Government of Cambodia and the Institut Pasteur (Paris, France).

The IPC plays a major role in life sciences and health research against emerging infectious diseases (human/animal) in cooperation with national and international partners. The IPC is a member of the Pasteur Network (33 institutions). In addition, following the 1992 agreement with the RGC and IP (Paris), together with HE Prof. MAM Bunheng, Cambodian Minister of Health, Prof. Stewart COLE, General Director of the Institut Pasteur (Paris) is the co-chair of IPC annual administrative board. As of September 2021, the IPC Directorate is composed of a Director, Prof. André Spiegel, a Deputy Director, Dr. LY Sowath (MoH and IPC senior researcher), and a Chief Financial Officer, Mr. Christophe MOUSSET (IP, Paris).

The IPC is composed of several entities: an administrative and financial department (including lab maintenance and metrology), several public services (Medical Biology Laboratory (LBM), Laboratory for Environment and Food Safety (LEFS), International Vaccination Center, three rabies prevention centers (Phnom Penh, Kampong Cham and Battambang), five research units (Immunology, Entomology, Virology, Malaria, and Epidemiology/Public Health) and four research groups (AMR/TB, Clinical Research, One Health and Geohealth) and a Metrology shared service. The IPC hosts permanent local researchers (n = 8) and 9 international researchers seconded from Institut Pasteur (Paris, n = 6), French National Research Institute for Sustainable Development (IRD, n = 2) and French Agricultural Research for Development (CIRAD, n= 1). In addition, several senior researchers and post-doctorates are working on specific projects. As of December 2020, 32 scientists are present on the campus for a total staff of around 290 people (14 nationalities).  The IPC benefits from the support of several international cooperation and development partners to ensure its missions. 

The IPC is also involved in post-graduate-level training. Each year, the IPC hosts around 100 students in the areas of biomedical sciences and engineering, as well as master and doctoral students in life sciences from different universities based in Cambodia and in other countries. The IPC is also a first line partner of the International Masters for Infectiology from the University of Health Sciences (UHS, Phnom Penh) and University Paris-Saclay (France).

The IPC’s laboratories are among the most efficient in Cambodia and Southeast Asia (SEA) for the diagnosis and study of pathogen transmission, analyses of biological and genetic markers for severity or antimicrobial resistance (AMR), human/animal infectious disease prevention and clinical research

IPC History

Creation of the Institut Pasteur du Cambodge, following the proclamation of the independence of the Kingdom of Cambodia (Directors: Dr. Maurice Huard from 1953 to 1955, and Dr. René Triau, 1955-1958). The Institute produced first veterinary vaccines but soon increased its capacity for human vaccines against rabies and smallpox.

The name was given of Institut Pasteur du Cambodge and its tasks were directed towards human biology and pathology. (Directors: 1958-1960: Dr. René Triau, 1960 – 1975: Dr. Yves GOUEFFON). In 1961, Dr. Claude Chastel created the service of human virology and medical entomology, and isolated Chikungunya virus (1961), dengue virus (1962) and Japanese encephalitis virus (1965). 

The Institut Pasteur du Cambodge is located in Toul Kork reborn under the direction of Mrs. Dr. Kruy Sunlay. Biological and microbiological analyzes (parasites, dengue, diarrhea) were developed and academic education was provided for medical staff.

A convention between the Government of Cambodia and the Institut Pasteur du Cambodge was signed in Phnom Penh by Professor Maxime Schwartz, Director General of the Institut Pasteur and Dr. Yim Chhay Ly for the State of Cambodia.

The foundation stone was celebrated by the French Minister of Health, Mrs Simone Veil and Dr. Chhea Tang, Minister of Health of Cambodia in the presence of Prof. Maxime Schwartz, Director General of the Institut Pasteur.

 The Institut Pasteur du Cambodge was officially opened by the Prime Minister of the Royal Government of Cambodia, Prince Norodom Ranariddh, in the presence of Prof Bernard Debré, French Minister of Cooperation. Dr. François Flye Sainte-Marie is officially the direction of the Institute and Ms. Kruy Sunlay, behind the rebirth of the Institut Pasteur du Cambodge, was appointed Deputy Director. The IPC opened a new era and Khmer-French cooperation.

A ceremony to celebrate the 60th anniversary of the Institut Pasteur du Cambodge, took place in the presence of Dr Mam Bunheng and Pr Alice Dautry, Director General of Institut Pasteur. On this occasion will be the laying of the foundation stone of a building for a regional cross-disciplinary

In 2023, the Institut Pasteur du Cambodge celebrated 70 years of presence in the country. Several events were organized for the occasion: a cocktail party at the French Embassy on May 23, a photographic exhibition from May to October on the wall of the French Embassy, conferences at the Institut Français du Cambodge in June and September, and a Gala Dinner for all IPC employees on December 8 at the Sokha Phnom Penh Hotel & Residence. A historical booklet, posters and medals have also been designed to commemorate the 70th anniversary.

Main National Partners

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• IPC WEBMAIL
• Institut Pasteur du Cambodge 2021