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Phenergan (Promethazine) against motion sickness and nausea

The unpleasant symptoms of travel sickness (aeroplane, ship, car or bus) can be prevented by a drug called Phenergan. Its active ingredient is called Promethazine. It is an antihistamine that helps to prevent the effects of histamine in the body, helping you to avoid many unpleasant symptoms associated with travelling. It must be taken as a preventative measure to get the best possible effect to make the trip to the destination as easy going as possible.

What’s on this page?

How does phenergan work.

The active ingredient in this medicine is Promethazine. The focus of the treatment is the class of sedative antihistamines (calming antihistamine), after taking the pill it therefore prevents histamine from affecting. It can reduce the irritating symptoms associated with movement disorders such as nausea and dizziness. In order to fully understand how this drug works, we must first look at what the antihistamines are and how they work in the body.

How do antihistamines work in motion?

Histamines are natural substances in the body, usually found from the immune system. When the body experiences imbalance it releases histamine that binds to different receptors. This can then cause disturbing symptoms. For someone who is allergic to histamines, they can cause itching around the eyes and a runny nose, while others may have symptoms of motion sickness such as, nausea, vomiting and dizziness. Imbalance occurs when the eye sees a different movement than what the inner ear feels.

Antihistamines inhibit histamines from binding to certain receptors, so there is no “space” for histamines. When histamines cannot bind to these receptors, the symptoms of motion sickness are prevented.

The effect is best when the antihistamines are taken before the symptoms develop. In this way, histamines cannot bind in certain areas. However, it may also be helpful if the drug is taken after the onset of symptoms because the antihistamines are so powerful that they can push the histamine away from the receptors.

Sedative or soothing effect

Phenergan belongs to the category of sedative antihistamines, so it is not suitable to be used if you plan to drive a car. It can only be used if you are a passenger in a car or a ship, plane, train or bus. However, it should be noted that everyone feels the effects of Phenergan differently, so some might still be close to their normal state while others might feel very sleepy.

Phenergan 25 mg: How should I use it?

This medicine is available in various forms, both in tablets and as an oral solution. The oral solution is typically used by children – however, only according to the doctor’s instructions. The tablets for adults contain 25 mg of the active substance and are taken with a glass water.

For the best effect, it is best to take the tablet before the start of the movement, i.e. about 30 to 60 minutes before the expected start. The effects of the medicine last around 5 to 14 hours in the blood stream and therefore it lasts during the whole trip for most people.

Remember that you may become very drowsy and your muscles may become tired after taking the medicine. However, the effect may differ between people and after you have used it a couple of times. After use, you can quickly understand how much the medicine affects you.

Alcohol can weaken the effects of the drug and therefore it is not recommended to drink alcohol and use the medicine simultaneously.

Are there any side effects?

All medicines can cause side effects to some extent. This is, among other things, the reason why most medicines can only be purchased with a prescription from a doctor. This also applies to Phenergan, although most do not experience any side effects. The most common side effects are a dry mouth and feeling fatigue, as mentioned earlier. Some have side effects such as dizziness, lack of urination, blurred vision and confusion. Rare side effects include anemia and allergic reactions. If you notice any serious side effects, contact your doctor immediately.

Is Phenergan suitable for me?

Most people who suffer from motion sickness while travelling either on the sea or in the air can take advantage of this medicine. However, care should be taken with regard to the simultaneous use of other medicines or other conditions you might be experiencing. This applies to situations in which you have sleep apnea, impaired hepatic or renal function or glaucoma. In addition, it may also affect with many antidepressants and sedatives.

Is there other natural options for Phenergan?

In addition to preventative medicines, there are other measures you can take to reduce discomfort during the movement:

make sure you get enough rest before your trip
drink a lot of water
if possible, get fresh air – stop the car and have breaks while driving, spend time up on the deck while on a ship or try to go out from the airport
be sure to look out from the window and avoid reading

Can I buy Phenergan online?

Phenergan is a prescription medication. You can visit your doctor and get a prescription that you can then use in a pharmacy when buying the medicine. Another possibility is to purchase the drug through an approved online clinic where your doctor will digitally assess whether the medicine is suitable for you or not. If the drug is right for you, you get a digital prescription and the medication can be sent to your home. This process saves you a lot of time, as you do not have to book a time from the doctor or go to the clinic physically.

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Promethazine for Kids: Uses, Dosages, Warnings

Warning on using promethazine for kids.

Phenergan for Vomiting
Side Effects/Warnings
Alternatives
When to Call a Doctor

Phenergan (promethazine) is an antiemetic (a medication that helps stop vomiting ). Healthcare providers may prescribe promethazine for kids when they are unable to keep fluids down and are at risk for dehydration.

Promethazine is approved for use in children over the age of 2 but carries a boxed warning that it may cause death in children and can slow or stop breathing. The medication can also cause serious side effects and hallucinations.

This article discusses promethazine for kids and adults. It explains the side effects of promethazine and dosing information. It also offers alternatives to promethazine to help stop vomiting and prevent dehydration.

Promethazine use in children comes with a few boxed warnings from the U.S. Food and Drug Administration (FDA):

Promethazine may cause breathing to slow or stop and may cause death in children.
It should not be given to babies or children who are younger than 2 years old and should be given with caution to children who are 2 years of age or older.
Combination products containing promethazine and codeine should not be given to children younger than 16 years old.

Promethazine may cause respiratory depression (hypoventilation), which can cause slow heart rate, shortness of breath, coma, and death unless promptly treated. The FDA issued this warning after several children stopped breathing or went into cardiac arrest after taking the drug.

Promethazine injections are also associated with severe tissue injury, that may give rise to gangrene or necrosis (tissue death), requiring amputation.

Promethazine to Treat Vomiting

Promethazine is an antiemetic drug used for vomiting. It's also used as an antihistamine (allergy pill) and a sedative (sleeping pill). It's available as tablets, suppositories, injectables, or syrups.

Phenergan should never be used in children less than 2 years of age. You and your pediatrician should consider alternatives in children over age 2, as well, due to the risk of dangerous side effects.

Promethazine can be given as an oral tablet, liquid medication, suppository, or injection. Dosing is based on body weight. It comes in 12.5 milligrams (mg), 25 mg, or 50 mg tablets.

In children older than 2 years of age, the recommended dose is 0.5 mg of promethazine per pound of body weight. A typical dose is 25 mg taken every four to six hours as needed.

Is Promethazine Available OTC?

Promethazine is not available over the counter. It can potentially cause life-threatening side effects and requires a prescription from a healthcare provider.

Side Effects

Side effects of promethazine in kids include:

Hallucinations
Dystonic reactions in children (muscle spasms or contractions causing involuntary movements)

These side effects occurred at a wide variety of doses.

Even if your child does not have serious respiratory depression, drowsiness related to the medication can interfere with treatment of vomiting. If your child is sleeping, he isn't drinking fluids and can become even more dehydrated.

Does Promethazine Affect Heart Rate?

Both slow heart rate (bradycardia) and rapid heart rate (tachycardia) are possible side effects of Phenergen. Children are more at risk.

Alternatives to Promethazine

Fortunately, when it comes to a vomiting child, you have a lot of alternatives that appear to be much safer than promethazine. These include both things you can do yourself at home and different medications.

Home Remedies

Home measures can be very helpful and are recommended by the World Health Organization.

With mild dehydration , your child may act thirsty and have a dry mouth. The first thing to try is oral rehydration solutions that restore fluids and replace lost electrolytes. You can buy products such as Enfalyte, Pedialyte, or Gatorade, or you can make your own rehydration solution from ingredients in your kitchen.

Not only are homemade solutions just as effective as store-bought options, but they're much cheaper and allow you to avoid the food dyes present in many from the store.

One of the biggest mistakes in encouraging your child to drink fluids is to give them too much too fast. It's hard not to give them all they want, especially if they're complaining about thirst, but going slow will help the fluids "stay down."

With moderate or severe dehydration , you may notice fewer wet diapers, sunken eyes, a lack of tears when the child cries, and listlessness. These are serious signs and you should get medical attention right away.

For vomiting, it's recommended that you begin by providing 1 teaspoon up to 1 tablespoon (3 teaspoons) of an oral electrolyte solution every five to 10 minutes.

The total amount of fluid your child will need depends on their degree of dehydration and can be estimated with a simple formula.

As your child's nausea improves, and especially if they have diarrhea, you may wish to slowly introduce foods back into their diet. You can give foods like bread, potatoes, or rice along with lean meat, yogurt, fruits, and vegetables. Avoid foods high in fat as they are harder to digest.

If your child also has diarrhea, the BRAT diet (bananas, rice, applesauce, toast) may help firm the stool, but it doesn't have enough nutrients to be used for an extended time. (The American Academy of Pediatrics no longer recommends this diet and favors oral hydration.)

Medications

If an antiemetic medication is necessary, there are now many alternatives.

One of the most commonly used alternative medications for children is Zofran (ondansetron). Zofran is approved for the treatment of chemotherapy-induced nausea and vomiting but is often used "off-label" for treating the "stomach flu," medically known as acute gastroenteritis in children.

When used for children with stomach flu , Zofran has been found to reduce the chance that a child will need intravenous fluids (which requires hospitalization). Zofran can be used even in younger children for whom Phenergan is not recommended.

Zofran comes with a warning as well—the injectable form can change the electrical activity of the heart, which can increase the risk of a potentially fatal heart rhythm. However, that only happens with the much higher doses required for chemotherapy, not the doses used for stomach flu.

This medication can also be quite expensive, as well.

When to Call a Healthcare Provider

Promethazine can lead to serious side effects. Contact a healthcare provider right away for any of the following:

Breathing difficulties, including slowed or paused breathing and wheezing
Decreased alertness, confusion, or fainting
Difficulty swallowing
Fast or irregular pulse or heartbeat
Muscle spasms

Seek emergency medical treatment for any of the following:

Green-tinged or blood-tinged vomit
Blood in the vomit or stool
Abdominal pain that starts near the navel and spreads to the lower right abdomen

These could be signs of appendicitis, which is a medical emergency.

Promethazine is helpful for preventing severe dehydration from vomiting. However, it can also cause serious side effects and should be used with caution in children. It can lead to respiratory failure and death, should not be given to children under the age of 2, and should not be taken with opioids in children under age 16.

If your child is vomiting and at risk of dehydration, another antiemetic Zofran is considered a safer alternative to promethazine. Talk to your child's healthcare provider about any concerns you have with this or any other medications.

U.S. National Library of Medicine: MedlinePlus. Promethazine .

U.S. National Library of Medicine, DailyMed. Label: Phenergan-promethazine hydrochloride injection .

U. S. Food and Drug Administration, Access Data. Wyeth Pharmaceuticals, Inc. Phenergan (promethazine HCI) Tablets and Suppositories .

Vega RM, Avva U. Pediatric dehydration . StatPearls.

Churgay CA, Aftab Z. Gastroenteritis in children: Part II. Prevention and management . Am Fam Physician . 2012;85(11):1066–1070.

Fedorowicz Z, Jagannath VA, Carter B. Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents . Cochrane Database of Systematic Reviews . doi:10.1002/14651858.cd005506.pub5

U.S. Food and Drug Administration. FDA Drug Safety Communication: New information regarding QT prolongation with ondansetron (Zofran) .

Stanford Children's Health, Lucile Packard Children's Hospital. Could that stomachache in your child be appendicitis?

Lorenzo C. Patient education: Nausea and vomiting in infants and children (Beyond the Basics) .

By Vincent Iannelli, MD Vincent Iannelli, MD, is a board-certified pediatrician and fellow of the American Academy of Pediatrics. Dr. Iannelli has cared for children for more than 20 years.

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Promethazine For Children: Dosage And Side Effects

This anti-allergy drug is administered as per the child’s age and medical condition.

Dr. Salla Semmane is a practicing pediatrician in Rabat in the district of Hassan, Morocco. Born in Finland, she completed her medical studies at the Faculty of Medicine in Kuopio and had her Licentiate of Medicine in 1989. She received the... more

Dr. Joyani Das did her post-graduation from Birla Institute of Technology, Mesra and PhD in Pharmacology. Previously, she worked as an associate professor, faculty of Pharmacology, for two years. With... more

Dr. Ritika Shah is a certified lactation counsellor (CLC) from iNational Health Care Academy, Singapore and a dental surgeon with more than seven years of clinical experience across various cities in ... more

Vidya did her post-graduation in Biotechnology from Osmania University, Hyderabad. Her interest in scientific research and writing made her pursue a career in writing, in which she now has over five y... more

MomJunction believes in providing reliable, research-backed information to you. As per our strong editorial policy requirements, we base our health articles on references (citations) taken from authority sites, international journals, and research studies. However, if you find any incongruencies, feel free to write to us .

Image: Shutterstock

Promethazine is an antihistamine drug that provides symptomatic relief from the common cold and flu, allergies, short-term sleep issues, vomiting, and nausea due to vertigo/motion sickness.

While generally safe, Promethazine for kids must be administered with caution as it is a sedative drug and is likely to induce sleepiness and is sometimes used as a sleep aids ( 1 ). Some brand names under which Promethazine is available over the counter (OTC) are Phenergan, Avomin, and Sominex.

Keep reading to know more about the safety, uses, and side effects of Promethazine for kids.

What Is Promethazine?

Promethazine, a first-generation antihistamine, belongs to the phenothiazine class of drugs. It acts by reducing the actions of natural substances in the body, such as histamine, dopamine i X A chemical that transport messages among nerve cells and also acts as a hormone that induces happiness and motivation. , and acetylcholine i X A signaling molecule that plays a significant role in several physiological functions of the body. . The US Food and Drug Administration (FDA)-approved uses of Promethazine include ( 2 ) ( 3 ):

Allergies. In the US, about 18.9% of children suffer from seasonal allergies, according to the Centers for Disease Control and Prevention (CDC) . Seasonal allergies (allergic rhinitis) causing runny nose and watery eyes, allergic conjunctivitis along with skin conditions causing itching and swelling can be treated with Promethazine. In addition, it can also be used in combination with other drugs to treat severe life-threatening allergic reactions (anaphylaxis).
Nausea and vomiting due to anesthesia, chemotherapy i X A treatment modality that uses chemicals to inhibit or prevent the growth of cancerous cells in the body. , or post-surgery effects.
Motion sickness. Most effective when given 30 minutes to one hour before travel or other trigger factors.
Sedation. Used along with painkillers to calm patients before or after surgery.

Is Promethazine Safe For Children?

The FDA contraindicates the use of Promethazine tablets or suppositories in pediatric patients below two years of age . It should be used with caution in children aged two years and above due to the risk of breathing problems (respiratory depression). Promethazine is not recommended for uncomplicated vomiting in children but only when vomiting is prolonged and due to a diagnosed condition. Children below 16 years of age should not use some products that contain Promethazine in combination with other drugs. You should consult a pediatrician before giving Promethazine to your child ( 2 ) ( 4 ).

What Is The Dosage Of Promethazine For Children?

Promethazine is available as tablets, syrups, suppositories, and injectable solutions. Seek a pediatrician’s prescription before giving this drug to children. The following table may help you understand the Promethazine dosage, with reference to Phenergan brand oral tablets, syrups, and rectal suppositories containing Promethazine HCl for pediatric patients ( 4 ).

Note: Promethazine HCl syrup contains 5-6.25mg drug per 5ml of liquid. Dosage to be calculated accordingly ( 5 ). Promethazine suppositories and tablets are available in 12.5mg dosage. Before using Promethazine or Phenergan for kids, consult a doctor to know the appropriate dosage and form based on your child’s condition.

What Are The Side Effects Of Promethazine In Children?

Promethazine may have the following common side effects ( 2 ).

Sleep disturbances
Nervousness
Excitability
Ringing in ears
Stuffy nose
Blurred vision

Seek medical advice if these become severe or are not resolved in a few days. Serious adverse effects that need immediate medical help include:

Wheezing or difficulty breathing
Slowed breathing or breathing stops for a short time
Irregular or increased heart rate
Low blood pressure
Muscle stiffness
Uncoordinated movements or unusual face and tongue movement
Hallucinations
Seizures i X Sudden and abnormal surge of electrical activity in the brain characterized by jerking body movements and loss of consciousness.
Involuntary shaking of body parts
Unusual bruising or bleeding
Yellow skin or eyes
An allergic reaction (rash, hives, swelling of the face, eyes, lips, tongue, throat, arms, hands, feet, ankles, or lower legs, dermatitis, or eczema)

Neuroleptic malignant syndrome (NMS) is a rare yet potentially fatal side effect of Promethazine. Contact a doctor immediately if you see symptoms such as fever, muscle cramps, severe headache, confusion, increased or abnormal heartbeat, or excess sweating.

What Are The Precautions To Be Taken When Using Promethazine?

Promethazine has several side effects that mandate precautions for safe usage of Promethazine in children ( 6 ).

Inform the doctor if your child has respiratory problems, such as asthma, chronic obstructive pulmonary disease (COPD) or sleep apnea , liver disorders or Reye’s syndrome, or allergy to sulfites . Promethazine might be contraindicated for children with these conditions.
Promethazine increases the likelihood of seizures. Talk to the doctor if your child is prone to or has had seizures in the past.
Discuss with your child’s doctor if your child is on any other medicines, health supplements, or herbal products. Phenothiazine may have drug interactions. Conversely, inform the healthcare provider about your child’s Promethazine usage when seeking medication for any other condition.
Refrain from involving your child in activities requiring alertness, such as riding a bike or skateboarding, since Promethazine may cause drowsiness and diminished alertness as a side effect.
Monitor blood sugar in children with diabetes.
Make sure to use only the prescribed dose for the duration instructed. Do not suddenly stop or increase the dose without consulting a doctor.
Use the measuring tool provided with the package for syrups to ensure the correct dosage.
Check the list of ingredients of all other medicines/products administered to the child to avoid an accidental overdose of Promethazine.
Make sure to check the ingredient list to spot any inactive ingredients that may cause allergies in your child.
Promethazine may make your child’s skin more sensitive to sunlight. Use sunscreens or protective clothing whenever your child needs to go out in the sun.
Keep the medication out of children’s reach in child-proof containers. Accidental overdose can be fatal.

Frequently Asked Questions

1. Does Promethazine have codeine in it?

Yes, Promethazine can be present in combination with codeine phosphate to relieve cough temporarily and also for upper respiratory symptoms linked with allergy or common cold ( 9 ).

2. Does Promethazine help with anxiety?

Promethazine is not used to treat anxiety before and after surgery. However, the use and dose for your child should be determined by the doctor ( 10 ).

3. How should promethazine be stored?

Promethazine in tablet and liquid forms should be stored at room temperature, away from heat and moisture, and the suppositories should be stored in the refrigerator. Thus, all forms of promethazine should be kept away from sunlight ( 2 ).

Despite its effectiveness in treating allergies, nausea, and vomiting in children and adults, Promethazine is only available as a prescription drug due to its ability to induce sleepiness. Instead, second-generation antihistamines i X A class of medications used to treat allergies by blocking the action of histamines (allergens). , such as Loratadine (Claritin), Cetirizine (Zyrtec), and Fexofenadine (Allegra), are recommended over Promethazine for children with allergies due to fewer adverse effects ( 7 ), while Ondansetron (Zofran) is used as an antiemetic alternative in children aged four and up ( 8 ). So, consult a pediatrician to determine when Promethazine can be prescribed for children.

Infographic: More About Promethazine Suppositories For Children

Illustration: Momjunction Design Team

Key Pointers

Promethazine is an antihistamine drug to manage allergies, motion sickness, nausea, vomiting, sedation, etc.
The FDA recommends against using promethazine for children under two years and suggests cautious use for children above two years.
Drowsiness, dry mouth, nightmares, blurred vision, etc., are a few side effects of promethazine in children.

Image: Dalle E/MomJunction Design Team

Promethazine (Phenergan). https://www.nhs.uk/medicines/promethazine/
Promethazine. https://medlineplus.gov/druginfo/meds/a682284.html
Brittin T. Southard and Yasir Al Khalili; (2021); Promethazine. https://www.ncbi.nlm.nih.gov/books/NBK544361/
Phenergan (promethazine HCI). https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/07935s030lbl.pdf
Promethazine hydrochloride syrup. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=85f183af-6781-4ceb-9c21-c4ee9a06c355&type=display
Promethazine Pediatric Medication. https://www.mskcc.org/cancer-care/patient-education/medications/pediatric/promethazine
Roisin Fitzsimon et al.; (2015); Antihistamine use in children. https://ep.bmj.com/content/100/3/122
Zofran. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020103s035_020605s019_020781s019lbl.pdf
Promethazine HCl and Codeine Phosphate Oral Solution; https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/008306s033lbl.pdf
Promethazine (Oral Route); https://www.mayoclinic.org/drugs-supplements/promethazine-oral-route/proper-use/drg-20070609?p=1
Promethazine. https://www.mskcc.org/cancer-care/patient-education/medications/adult/promethazine
Fact-checker

Dr. Salla Semmane MD

Dr. joyani das m.pharm, phd, dr. ritika shah bds, clc, vidya tadapatri msc (biotechnology), latest articles, pityriasis rosea in children: symptoms, causes and treatment.

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Motion sickness

Travel sickness.

Peer reviewed by Dr Hayley Willacy, FRCGP Last updated by Dr Colin Tidy, MRCGP Last updated 16 Mar 2023

Meets Patient’s editorial guidelines

In this series: Health advice for travel abroad Travelling to remote locations Ears and flying Jet lag Altitude sickness

Motion sickness (travel sickness) is common, especially in children. It is caused by repeated unusual movements during travelling, which send strong (sometimes confusing) signals to the balance and position sensors in the brain.

What causes motion sickness, how long does motion sickness last, motion sickness symptoms, how to stop motion sickness, natural treatments for motion sickness, motion sickness medicines, what can a doctor prescribe for motion sickness, what should i do if i'm actually sick, what is mal de debarquement syndrome.

Continue reading below

Motion sickness is a normal response to repeated movements, such as going over bumps or around in a circle, send lots of messages to your brain. If you are inside a vehicle, particularly if you are focused on things that are inside the vehicle with you then the signals that your eyes send to the brain may tell it that your position is not changing, whilst your balance mechanisms say otherwise.

Your balance mechanisms in your inner ears sense different signals to those that your eyes are seeing which then sends your brain mixed, confusing messages. This confusion between messages then causes people to experience motion sickness.

Is motion sickness normal?

Motion sickness is a normal response that anyone can have when experiencing real or perceived motion. Although all people can develop motion sickness if exposed to sufficiently intense motion, some people are rarely affected while other people are more susceptible and have to deal with motion sickness very often.

Triggers for motion sickness

Motion sickness can also be triggered by anxiety or strong smells, such as food or petrol. Sometimes trying to read a book or a map can trigger motion sickness. Both in children and adults, playing computer games can sometimes cause motion sickness to occur.

Motion sickness is more common in children and also in women. Fortunately, many children grow out of having motion sickness. It is not known why some people develop motion sickness more than others. Symptoms can develop in cars, trains, planes and boats and on amusement park rides, etc.

Symptoms typically go when the journey is over; however, not always. In some people they last a few hours, or even days, after the journey ends.

There are various symptoms of motion sickness including::

Feeling sick (nausea and vomiting).

Sweating and cold sweats.

Increase in saliva.

Headaches .

Feeling cold and going pale.

Feeling weak.

Some general tips to avoid motion sickness include the following.

Prepare for your journey

Don't eat a heavy meal before travelling. Light, carbohydrate-based food like cereals an hour or two before you travel is best.

On long journeys, try breaking the journey to have some fresh air, drink some cold water and, if possible, take a short walk.

For more in-depth advice on travelling generally, see the separate leaflets called Health Advice for Travel Abroad , Travelling to Remote Locations , Ears and Flying (Aeroplane Ear) , Jet Lag and Altitude Sickness .

Plan where you sit

Keep motion to a minimum. For example, sit in the front seat of a car, over the wing of a plane, or on deck in the middle of a boat.

On a boat, stay on deck and avoid the cafeteria or sitting where your can smell the engines.

Breathe fresh air

Breathe fresh air if possible. For example, open a car window.

Avoid strong smells, particularly petrol and diesel fumes. This may mean closing the window and turning on the air conditioning, or avoiding the engine area in a boat.

Use your eyes and ears differently

Close your eyes (and keep them closed for the whole journey). This reduces 'positional' signals from your eyes to your brain and reduces the confusion.

Don't try to read.

Try listening to an audio book with your eyes closed. There is some evidence that distracting your brain with audio signals can reduce your sensitivity to the motion signals.

Try to sleep - this works mainly because your eyes are closed, but it is possible that your brain is able to ignore some motion signals when you are asleep.

Do not read or watch a film.

It is advisable not to watch moving objects such as waves or other cars. Don't look at things your brain expects to stay still, like a book inside the car. Instead, look ahead, a little above the horizon, at a fixed place.

If you are the driver you are less likely to feel motion sickness. This is probably because you are constantly focused on the road ahead and attuned to the movements that you expect the vehicle to make. If you are not, or can't be, the driver, sitting in the front and watching what the driver is watching can be helpful.

Treat your tummy gently

Avoid heavy meals and do not drink alcohol before and during travelling. It may also be worth avoiding spicy or fatty food.

Try to 'tame your tummy' with sips of a cold water or a sweet, fizzy drink. Cola or ginger ale are recommended.

Try alternative treatments

Sea-Bands® are acupressure bands that you wear on your wrists to put pressure on acupressure points that Chinese medicine suggests affects motion sickness. Some people find that they are effective.

Homeopathic medicines seem to help some people, and will not make you drowsy. The usual homeopathic remedy is called 'nux vom'. Follow the instructions on the packet.

All the techniques above which aim to prevent motion sickness will also help reduce it once it has begun. Other techniques, which are useful on their own to treat motion sickness but can also be used with medicines if required, are:

Breathe deeply and slowly and, while focusing on your breathing, listening to music. This has been proved to be effective in clinical trials.

Ginger - can improve motion sickness in some people (as a biscuit or sweet, or in a drink).

There are several motion sickness medicines available which can reduce, or prevent, symptoms of motion sickness. You can buy them from pharmacies or, in some cases, get them on prescription. They work by interfering with the nerve signals described above.

Medicines are best taken before the journey. They may still help even if you take them after symptoms have begun, although once you feel sick you won't absorb medicines from the stomach very well. So, at this point, tablets that you put against your gums, or skin patches, are more likely to be effective.

Hyoscine is usually the most effective medicine for motion sickness . It is also known as scopolamine. It works by preventing the confusing nerve messages going to your brain.

There are several brands of medicines which contain hyoscine - they also come in a soluble form for children. You should take a dose 30-60 minutes before a journey; the effect can last up to 72 hours. Hyoscine comes as a patch for people aged 10 years or over. (This is only available on prescription - see below.) Side-effects of hyoscine include dry mouth , drowsiness and blurred vision.

Side-effects of motion sickness medicines

Some medicines used for motion sickness may cause drowsiness. Some people are extremely sensitive to this and may find that they are so drowsy that they can't function properly at all. For others the effects may be milder but can still impair your reactions and alertness. It is therefore advisable not to drive and not to operate heavy machinery if you have taken them. In addition, some medicines may interfere with alcohol or other medication; your doctor or the pharmacist can advise you about this.

Antihistamines

Antihistamines can also be useful , although they are not quite as effective as hyoscine. However, they usually cause fewer side-effects. Several types of antihistamine are sold for motion sickness. All can cause drowsiness, although some are more prone to cause it than others; for example, promethazine , which may be of use for young children on long journeys, particularly tends to cause drowsiness. Older children or adults may prefer one that is less likely to cause drowsiness - for example, cinnarizine or cyclizine.

Remember, if you give children medicines which cause drowsiness they can sometimes be irritable when the medicines wear off.

See the separate article called How to manage motion sickness .

There are a number of anti-sickness medicines which can only be prescribed by your doctor. Not all of them always work well for motion sickness, and finding something that works may be a case of trial and error. All of them work best taken up to an hour before your journey, and work less well if used when you already feel sick. See also the separate leaflet called Nausea (Causes, Symptoms, and Treatment) for more detailed information about these medicines .

Hyoscine patch

Hyoscine, or scopolamine, patches are suitable for adults and for children over 10 years old. The medicine is absorbed through your skin, although this method of medicine delivery is slow so the patch works best if applied well before your journey.

You should stick the patch on to the skin behind the ear 5-6 hours before travelling (often this will mean late on the previous night) and remove it at the end of the journey.

Prochlorperazine

Prochlorperazine is a prescription-only medicine which works by changing the actions of the chemicals that control the tendency to be sick (vomit), in your brain. One form of prochlorperazine is Buccastem®, which is absorbed through your gums and does not need to be swallowed. Buccastem® tastes rather bitter but it can be effective for sickness when you are already feeling sick, as it doesn't have to be absorbed by the stomach.

Metoclopramide

Metoclopramide is a tablet used to speed up the emptying of your tummy. Slow emptying of the tummy is something that happens when you develop nausea and vomiting, so metoclopramide can help prevent this. It prevents nausea and vomiting quite effectively in some people. It can occasionally have unpleasant side-effects, particularly in children (in whom it is not recommended). Metoclopramide is often helpful for those who tend to have gastric reflux, those who have slow tummy emptying because of previous surgery, and those who have type 1 diabetes. Your GP will advise whether metoclopramide is suitable for you.

Domperidone

Domperidone , like metoclopramide, is sometimes used for sickness caused by slow tummy emptying. It is not usually recommended for motion sickness but is occasionally used if other treatments don't help. Domperidone is not a legal medicine in some countries, including the USA.

Ondansetron

Ondansetron is a powerful antisickness medicine which is most commonly used for sickness caused by chemotherapy, and occasionally used for morning sickness in pregnancy. It is not usually effective for motion sickness. This, and its relatively high cost means that it is not prescribed for motion sickness alone. However, for those undergoing chemotherapy, and for those who have morning sickness aggravated by travel, ondansetron may be helpful.

If you're actually sick you may find that this relieves your symptoms a little, although not always for very long. If you've been sick:

Try a cool flannel on your forehead, try to get fresh air on your face and do your best to find a way to rinse your mouth to get rid of the taste.

Don't drink anything for ten to twenty minutes (or it may come straight back), although (very) tiny sips of very cold water, coke or ginger ale may help.

After this, go back to taking all the prevention measures above.

Once you reach your destination you may continue to feel unwell. Sleep if you can, sip cold iced water, and - when you feel ready - try some small carbohydrate snacks. Avoid watching TV (more moving objects to watch!) until you feel a little better.

The sensation called 'mal de debarquement' (French for sickness on disembarking) refers to the sensation you sometimes get after travel on a boat, train or plane, when you feel for a while as though the ground is rocking beneath your feet. It is probably caused by the overstimulation of the balance organs during your journey. It usually lasts only an hour or two, but in some people it can last for several days, particularly after a long sea journey. It does not usually require any treatment.

Persistent mal de debarquement syndrome is an uncommon condition in which these symptoms may persist for months or years.

Dr Mary Lowth is an author or the original author of this leaflet.

Article History

The information on this page is written and peer reviewed by qualified clinicians.

Next review due: 14 Mar 2028

16 mar 2023 | latest version.

Last updated by

Peer reviewed by

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Generic name: promethazine (oral) [ pro-METH-a-zeen ] Brand names: Phenergan, Phenadoz , Promethegan Drug classes: Antihistamines , Phenothiazine antiemetics

Medically reviewed by Kaci Durbin, MD . Last updated on Feb 5, 2024.

The Phenergan brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available .

Phenergan is also found in combination with other medications such as phenylephrine (Prometh Hydrochloride), codeine (Prometh VC), or dextromethorphan (Promethazine DM)

What is Phenergan?

Phenergan belongs to a group of drugs called phenothiazines. It works by changing the actions of chemicals in your brain. Promethazine also acts as an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body.

Phenergan is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.

Phenergan also prevents motion sickness, and treats nausea and vomiting or pain after surgery. It is also used as a sedative or sleep aid.

Phenergan is not for use in treating symptoms of asthma, pneumonia, or other lower respiratory tract infections.

Stop using Phenergan and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects. Phenergan should not be given to a child younger than 2 years old. Phenergan can cause severe breathing problems or death in very young children. Carefully follow your doctor's instructions when giving this medicine to a child of any age.

Phenergan can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol, which can increase some of the side effects of Phenergan. There are many other medicines that can interact with promethazine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Before taking this medicine

Phenergan should not be given to a child younger than 2 years old. Phenergan can cause severe breathing problems or death in very young children. Carefully follow your doctor's instructions when giving this medicine to a child of any age.

You should not take Phenergan if you are allergic to promethazine or to similar medicines such as chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, thioridazine, or trifluperazine.

You should not take Phenergan if you have asthma or another lower respiratory tract disorder.

To make sure Phenergan is safe for you, tell your doctor if you have:

asthma, chronic obstructive pulmonary disease (COPD), sleep apnea, or other breathing disorder;

a sulfite allergy;

a history of seizures;

a weak immune system (bone marrow depression);

enlarged prostate or problems with urination;

stomach ulcer or obstruction;

heart disease or high blood pressure;

liver disease;

adrenal gland tumor (pheochromocytoma);

low levels of calcium in your blood (hypocalcemia); or

if you have ever had a serious side effect while using promethazine or any other phenothiazine.

It is not known whether Phenergan will affect an unborn baby. Animal studies have not shown any effects. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether promethazine passes into breast milk or if it could affect a nursing baby. Tell your doctor if you are nursing prior to using Phenergan.

How should I take Phenergan?

Take Phenergan exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Phenergan is often taken at bedtime or before meals. For motion sickness, Phenergan is usually started within 1 hour before traveling. When used for surgery, Phenergan is usually taken the night before the surgery.

How often you take Phenergan and the timing of your dose will depend on the condition being treated.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

If a child is using this medicine, tell your doctor if the child has any changes in weight. Phenergan doses are based on weight in children, and any changes may affect your child's dose.

Call your doctor if your symptoms do not improve, or if they get worse while using Phenergan.

This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Phenergan.

Store Phenergan at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include overactive reflexes, loss of coordination, severe drowsiness or weakness, fainting, dilated pupils, weak or shallow breathing, or seizure (convulsions).

What to avoid

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Drinking alcohol can increase certain side effects of Phenergan. Do not drink alcohol while taking this medication.

Avoid exposure to sunlight or tanning beds. Phenergan can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Phenergan side effects

Get emergency medical help if you have any signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Phenergan and call your doctor at once if you have:

severe drowsiness, weak or shallow breathing;

a light-headed feeling, like you might pass out;

confusion, agitation, hallucinations, nightmares;

seizure (convulsions);

fast or slow heartbeats;

jaundice (yellowing of the skin or eyes);

uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);

easy bruising or bleeding (nosebleeds, bleeding gums);

sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing; or

very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Side effects such as confusion and severe drowsiness may be more likely in older adults.

Common Phenergan side effects may include:

drowsiness, dizziness;

ringing in your ears;

double vision;

feeling nervous;

dry mouth; or

tired feeling, sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Phenergan?

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can interact with Phenergan and cause medical problems or increase side effects. Tell your doctor if you regularly use any of these medicines.

Also tell your doctor if you are using any of the following medicines:

lithium (Eskalith, Lithobid);

atropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);

blood pressure medication such as guanadrel (Hylorel), guanethidine (Ismelin), propranolol (Inderal), and others;

a blood thinner such as warfarin (Coumadin);

bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), and others;

a MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam) or methylene blue injection; or

medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor (prolactinoma); or

medicine to treat stomach ulcer or irritable bowel syndrome, such as dicyclomine (Bentyl), glycopyrrolate (Robinul), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), mepenzolate (Cantil), or propantheline (Pro-Banthine).

This list is not complete and there are many other medicines that can interact with Phenergan. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Frequently asked questions

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Other brands

Promethegan , Antinaus 50 , Phenadoz

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Related treatment guides

Allergic Reactions
Allergic Rhinitis
Anaphylaxis

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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Promethazine (Oral Route)

Description and brand names.

Drug information provided by: Merative, Micromedex ®

US Brand Name

Descriptions.

Promethazine is used to relieve or prevent the symptoms of hay fever, allergic conjunctivitis (inflammation of the eye), and other types of allergy or allergic reactions. It works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. It can sometimes close up the bronchial tubes (air passages of the lungs) and make breathing difficult .

Promethazine is also used to prevent and control motion sickness, nausea, vomiting, and dizziness. In addition, it may be used to help people go to sleep and control their pain or anxiety before or after surgery or other procedures .

Promethazine may also be used for other conditions as determined by your doctor .

This medicine is only available with your doctor's prescription .

This product is available in the following dosage forms:

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of promethazine in the pediatric population. Safety and efficacy have not been established in children below 2 years of age. Caution should be used when this medicine is given to children 2 years of age and older .

Insufficient information is available on the relationship of age to the effects of promethazine in geriatric patients. However, elderly patients may be more sensitive to the side effects of this medicine (such as confusion and severe drowsiness) than in younger adults, and are more likely to have age-related heart or blood vessel disease, liver problems, and kidney disease, which may require adjustment of dosage in patients receiving promethazine .

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Calcium Oxybate
Dronedarone
Levoketoconazole
Magnesium Oxybate
Mesoridazine
Piperaquine
Potassium Citrate
Potassium Oxybate
Sodium Oxybate
Sparfloxacin
Terfenadine
Thioridazine
Tranylcypromine
Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Amisulpride
Amitriptyline
Apomorphine
Aripiprazole
Aripiprazole Lauroxil
Arsenic Trioxide
Azithromycin
Benzhydrocodone
Buprenorphine
Butorphanol
Cannabidiol
Carbinoxamine
Chloroquine
Chlorpromazine
Ciprofloxacin
Clarithromycin
Clofazimine
Clomipramine
Clothiapine
Daridorexant
Desipramine
Deutetrabenazine
Dexmedetomidine
Dihydrocodeine
Disopyramide
Domperidone
Encorafenib
Entrectinib
Epinephrine
Erythromycin
Escitalopram
Fexinidazole
Flibanserin
Fluconazole
Fostemsavir
Gabapentin Enacarbil
Gatifloxacin
Gemifloxacin
Glycopyrrolate
Glycopyrronium Tosylate
Gonadorelin
Granisetron
Halofantrine
Haloperidol
Hydrocodone
Hydromorphone
Hydroxychloroquine
Hydroxyzine
Iloperidone
Inotuzumab Ozogamicin
Ketoconazole
Lemborexant
LetibotulinumtoxinA-wlbg
Levocetirizine
Levofloxacin
Levorphanol
Lumefantrine
Macimorelin
Methacholine
Metoclopramide
Metrizamide
Metronidazole
Mifepristone
Mirtazapine
Mobocertinib
Morphine Sulfate Liposome
Moxifloxacin
Norfloxacin
Nortriptyline
Oliceridine
Ondansetron
Osilodrostat
Osimertinib
Oxaliplatin
Oxymorphone
Paliperidone
Panobinostat
Pasireotide
Pentamidine
Pentazocine
Periciazine
Phenobarbital
Pimavanserin
Posaconazole
Procainamide
Procarbazine
Prochlorperazine
Propafenone
Protriptyline
Quizartinib
Remifentanil
Remimazolam
Revefenacin
Ropeginterferon Alfa-2b-njft
Scopolamine
Secretin Human
Selpercatinib
Sevoflurane
Sodium Phosphate
Sodium Phosphate, Dibasic
Sodium Phosphate, Monobasic
Solifenacin
Telithromycin
Tetrabenazine
Triclabendazole
Trifluoperazine
Trimipramine
Triptorelin
Vemurafenib
Venlafaxine
Voclosporin
Voriconazole
Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aminolevulinic Acid
Belladonna Alkaloids
Evening Primrose
Phenylalanine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Do not keep outdated medicine or medicine no longer needed.

Keep out of the reach of children.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects .

This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor .

This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert .

This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, antidepressants, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your medical doctor or dentist before taking any of the above while you are taking this medicine.

Check with your doctor right away if you have symptoms of pale or blue lips, fingernails, or skin; difficult or troubled breathing; irregular, fast, slow, or shallow breathing; or shortness of breath. These could be signs of a condition called respiratory depression .

Check with your doctor right away and stop taking your medicine (if directed by your doctor) if you have muscle stiffness, fever, difficult or fast breathing, seizures, fast heartbeat, increased sweating, loss of bladder control, unusually pale skin, or tiredness or weakness. These may be symptoms of a serious condition called neuroleptic malignant syndrome (NMS) .

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine .

This medicine may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections .

This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds .

This medicine controls nausea and vomiting. For this reason, it may cover up some of the signs of overdose caused by other medicines or the symptoms of encephalopathy or Reye's syndrome. This will make it difficult for your doctor to diagnose these conditions. Make sure your doctor knows that you are taking this medicine .

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking this medicine and get emergency help immediately if any of the following effects occur:

Convulsions (seizures)
difficult or unusually fast breathing
fast heartbeat or irregular pulse
high or low (irregular) blood pressure
increased sweating
loss of bladder control
severe muscle stiffness
unusually pale skin
unusual tiredness or weakness

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Abdominal or stomach pain
black, tarry stools
bleeding gums
blood in urine or stools
bloody nose
blurred vision
chest pain or discomfort
clay-colored stools
confusion as to time, place, or person
cough or hoarseness
decreased awareness or responsiveness
difficulty or troubled breathing
double vision
fast, pounding, or irregular heartbeat or pulse
fever with or without chills
fixed position of eye
heavier menstrual periods
holding false beliefs that cannot be changed by fact
hyperexcitability
increased or decreased blood pressure
irregular, fast or slow, or shallow breathing
large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
lightheadedness, dizziness, or fainting
loss of appetite
lower back or side pain
mimicry of speech or movements
nasal stuffiness
noisy breathing
not breathing
painful or difficult urination
pale or blue lips, fingernails, or skin
peculiar postures or movements, mannerisms or grimacing
pinpoint red spots on skin
seeing double
seeing, hearing, or feeling things that are not there
severe sleepiness
shortness of breath
slow or irregular heartbeat
sore throat
sores, ulcers, or white spots on lips or in mouth
sticking out of tongue
swollen glands
tightness in chest
uncontrolled twisting movements of neck
unpleasant breath odor
unusual bleeding or bruising
unusual excitement, nervousness, or restlessness
vomiting of blood
yellow eyes or skin

Symptoms of overdose

Discouragement
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
excessive muscle tone
feeling of warmth
feeling sad or empty
irritability
lack of appetite
loss of interest or pleasure
muscle tension or tightness
overactive reflexes
pupils of eyes large and not moving or responding to light
redness of the face, neck, arms and occasionally, upper chest
shakiness and unsteady walk
sudden death
trouble concentrating
trouble sleeping
unconsciousness
unsteadiness, trembling, or other problems with muscle control or coordination
unusual paleness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

blistering, crusting, irritation, itching, or reddening of skin
continuing ringing or buzzing or other unexplained noise in ears
cracked, dry, scaly skin
false or unusual sense of well-being
hearing loss
hives or welts
increased sensitivity of skin to sunlight
lack of coordination
loss of strength or energy
muscle pain or weakness
redness or other discoloration of skin
relaxed and calm
unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: April 01, 2024

Original article: https://www.mayoclinic.org/drugs-supplements/promethazine-oral-route/proper-use/DRG-20070609

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Phenergan (Promethazine Hydrochloride)

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For More Information Please Contact Us

Promethazine hydrochloride (Phenergan) is an antihistamine that relieves nasal stuffiness and inflammation and red, inflamed eyes caused by hay fever and other allergies, treats itching, swelling, and redness from hives and other rashes, allergic reactions to blood transfusions, a sedative and sleep aid for both children and adults, prevents and controls nausea and vomiting before and after surgery, and motion sickness.

How should it be used?

This medication is available in syrup, tablet, suppository and injection forms.

Tablet form:

Take by mouth with or without food or milk.
Take with a full glass of water.
Follow directions on how much to take, and when to take it, by your pharmacist or doctor.

Syrup form:

Take by mouth with or without food.
Measure liquid with a marked measuring spoon or medicine cup, not a regular spoon. If you do not have a dose-measuring spoon or cup, you can ask the pharmacist.

Suppository form:

Use only in the rectum. Do not use in the mouth.
Follow directions on how to use by the pharmacist or doctor.

Injection form:

Injection is usually given in the doctor’s office, hospital or clinic.
If using at home someone will teach you how to use it.
Follow the procedure you are taught when you use a dose.
Do not use if it contains particles, is cloudy or discolored, or if the vial is damaged.
If you are using for motion sickness, take dose at least 30-60 minutes before you start traveling.
Follow all rules in how to throw away the used needles and vials.

Phenergan may cause drowsiness, dizziness or blurred vision. Do not drive or do any activity where it will be unsafe until you know how you will react.

If you are taking this medicine on a regular schedule, take the missed dose as soon as you remember. If it is almost time for the next dose, don’t take the dose you missed. Wait and take the regular dose so you can get back to the regular schedule. Never take 2 doses at one time.

Special Precautions/Instructions

Before you start taking this medicine tell your doctor about any of the following:

All medications (including over the counter), vitamins, herbal products, and supplements you are taking.
o tablets: promethazine HCL, lactose, magnesium stearate, methylcellulose
o -12.5 mg dosage also contains: FD&C Yellow 6 and saccharin sodium
o -25 mg dosage also contains: saccharin sodium
o -50 mg dosage also contains: FD&C Red 40
o -Suppository: promethazine HCL, ascorbyl palmitate, silicon dioxide, white wax, and cocoa butter
Have a stomach ulcer
Have an enlarged prostate
Have narrow-angle glaucoma
Have an intestinal blockage
Have a bladder blockage
Have heart problems
Have liver problems
Have breathing or lung problems
Have sleep apnea
Have seizures
Drink alcohol
Are pregnant, plant to become pregnant, or breastfeeding.

This medication should NOT be used in:

Children less than 2 years old
Patients who are unconscious
Patients who are allergic to promethazine, any of the ingredients in promethazine, or to other phenothiazines
Patients with lung symptoms including asthma
Children who are vomiting unless the vomiting is prolonged and there is no known cause

Avoid prolonged exposure to the sun.

Avoid using with anticholinergics or tricyclic depressants, levodopa, lithium, MAO inhibitors, quinolones, or yohimbe.

Side Effects

The most common side effects include: drowsiness, changes in blood pressure, skin reactions, blood cell changes, and breathing problems.

Contact your doctor immediately if you experience signs of an allergic reaction including:

Feeling sick
Fever, shivering/chills, rash
Muscle and bone pain
Kidney problems (changes in the amount of urine or color of urine)
Tiredness, dizziness
Trouble breathing

Patient should immediately report any involuntary muscle movements.

For complete information, please visit: http://www.fda.gov/cder/drug/infopage/promethazine/default.htm

Storage Conditions

Medicine in the tablet form should be stored at room temperature (68 to 77 degrees F).
Store suppository in the refrigerator between 36-46 degrees F.
Keep out of reach of children.
Protect from sunlight and moisture.

Emergency/Overdose

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Promethazine (Phenergan) - Other brand names: Avomine, Sominex

On this page.

About promethazine
Who can and cannot take promethazine
How and when to take promethazine
Side effects
How to cope with side effects of promethazine
Pregnancy and breastfeeding
Cautions with other medicines
Common questions about promethazine

1. About promethazine

Promethazine is an antihistamine medicine that relieves the symptoms of allergies.

It's known as a drowsy (sedating) antihistamine, so it's more likely to make you feel sleepy than other antihistamines.

Promethazine is used for:

short-term sleep problems ( insomnia ) – including when a cough, cold or itching is keeping you awake at night
allergies, including hay fever and hives (urticaria)
feeling and being sick (vomiting) – due to motion sickness or vertigo
cold symptoms, such as coughing and a runny nose

You can buy promethazine from pharmacies, where it's often sold as Avomine, Phenergan or Sominex. Promethazine is also available on prescription.

It comes as tablets, capsules and a liquid that you swallow.

You can also buy promethazine mixed with other medicines, such as paracetamol , dextromethorphan or pseudoephedrine, to treat coughs and colds or pain.

2. Key facts

Do not drink alcohol while taking promethazine. Alcohol increases the risks of side effects.
To help you sleep, take promethazine 20 minutes before you go to bed. It normally takes about 30 minutes to work.
To prevent motion sickness, take promethazine the night before a long journey or 1 to 2 hours before a short journey.
Common side effects of promethazine include drowsiness, headaches, nightmares and feeling dizzy, restless or confused.
When promethazine is mixed with other medicines, it's also known by the brand names Fedril and Night Nurse.

3. Who can and cannot take promethazine

Promethazine can be taken by most adults.

Children under 6 should not be given cough and cold medicines containing promethazine if they have been bought at a pharmacy. These medicines should only be given if prescribed by a doctor.

Some types of promethazine medicines are not suitable for children over 6. Some are labelled 12+ and some are labelled 16+. Your doctor or pharmacist will advise which are the safest for children.

Promethazine is not suitable for some adults. To make sure it's safe for you, tell your doctor or pharmacist if you:

have ever had an allergic reaction to promethazine or any other medicine
have an eye problem called primary angle closure glaucoma
have problems peeing or emptying your bladder
have epilepsy or any other health problem that causes seizures or fits
are due to have an allergy test. Promethazine can affect your results, so you may need to stop taking it a few days before your test. Ask the clinic where you are due to have your allergy test
are unable to have any alcohol – some liquid promethazine products contain a very small amount of alcohol, so check the ingredients and the packaging carefully
are trying to get pregnant. Promethazine can affect home pregnancy tests. If you think you're pregnant, speak to your doctor so they can arrange a blood test instead

4. How and when to take promethazine

If you or your child have been prescribed promethazine, follow your doctor's instructions about how and when to take it.

Only take promethazine when you need it – for example, if you're unable to sleep because you're worrying about something or your cold symptoms are keeping you awake.

If you have bought promethazine or any medicine containing promethazine from a pharmacy, follow the instructions that come with it, or ask a pharmacist for advice.

Dosage and strength

Promethazine comes in 10mg, 20mg and 25mg tablets. Your dose depends on why you're taking it:

short-term insomnia – you'll usually take 20mg to 50mg at night
hay fever – you'll usually take from 10mg twice a day to 20mg, 3 times a day
hives – you'll usually take from 10mg twice a day to 20mg 3 times a day
preventing motion sickness – you'll usually take 25mg 1 to 2 hours before a short journey or 25mg the night before a long journey
treating motion sickness – take 25mg as soon as possible and 25mg the same evening, followed by 25mg the following evening (if you need it)
vertigo – the dose can vary from 25mg a day to 25mg 4 times a day

If you're taking liquid which contains 5mg of promethazine in 5ml, follow the instructions that come with the medicine for how much to take.

Doses are lower for children. Your doctor will use your child's age to work out the right dose.

Promethazine mixed with other medicines

Promethazine can come mixed with other medicines, such as paracetamol. This is usually used to treat cough and cold symptoms. Your dose will depend on the type of medicine you're taking.

Check the instructions on the packaging carefully, or ask your pharmacist or doctor if you're unsure.

How to take it

You can take promethazine tablets, capsules and liquid with or without food.

How to take tablets and capsules

Always take your promethazine tablets or capsules with a drink of water. Swallow them whole. Do not chew them.

How to take liquid

Liquid medicines containing promethazine come with a plastic syringe or spoon to help you measure out the right dose.

If you do not have a syringe or spoon, ask your pharmacist for one. Do not use a kitchen teaspoon as you will not get the right amount.

What if I forget to take it?

For motion sickness, take it as soon as you remember.

For anything else, skip the missed dose and take your next dose at the usual time.

Never take 2 doses at the same time. Never take an extra dose to make up for a forgotten one.

If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

What if I take too much?

Too much promethazine can be dangerous.

If you take more than your usual dose, you may:

feel very sleepy
have a very fast, irregular or pounding heartbeat (palpitations)
have breathing problems

In serious cases, you can become unconscious or have seizures or fits and may need emergency treatment in hospital.

If your child takes too much promethazine, they may also:

move unsteadily or stumble
have uncontrolled movements, especially in their hands or feet
see or hear things that are not there (hallucinations)
have an irregular heartbeat

Urgent advice: Contact 111 for advice if:

you take more than your usual dose of promethazine

Go to 111.nhs.uk or call 111

If you need to go to A&E do not drive yourself. Get someone else to drive you or call for an ambulance.

Take the promethazine packet or leaflet inside it, plus any remaining medicine, with you.

5. Side effects

Common side effects.

Like all medicines, promethazine can cause side effects, although not everyone gets them.

Talk to your pharmacist or doctor if these side effects bother you or do not go away:

feeling tired during the daytime
feeling dizzy or unsteady on your feet, or having difficulty concentrating

Promethazine can sometimes make your skin more sensitive to sunlight. Keep out of direct or strong sunlight and follow sun safety advice .

If you're over 65, you're more likely to get side effects such as:

feeling confused
blurred vision
difficulty peeing

Talk to a doctor or call 111 straight away if you have these side effects.

Children are more likely to get side effects such as feeling restless or excited.

Serious side effects

Call your doctor straight away if:

the whites of your eyes or your skin turn yellow, although this may be less obvious on black or brown skin – these can be signs of liver problems
you notice more bruising or bleeding than normal
you have muscle stiffness or shaking, or unusual face or tongue movements

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction ( anaphylaxis ) to promethazine.

Immediate action required: Call 999 now if:

your lips, mouth, throat or tongue suddenly become swollen
you're breathing very fast or struggling to breathe (you may become very wheezy or feel like you're choking or gasping for air)
your throat feels tight or you're struggling to swallow
your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
you suddenly become very confused, drowsy or dizzy
someone faints and cannot be woken up
a child is limp, floppy or not responding like they normally do (their head may fall to the side, backwards or forwards, or they may find it difficult to lift their head or focus on your face)

You or the person who's unwell may also have a rash that's swollen, raised, itchy, blistered or peeling.

These can be signs of a serious allergic reaction and may need immediate treatment in hospital.

These are not all the side effects of promethazine. For a full list, see the leaflet inside your medicine packet.

You can report any suspected side effect using the Yellow Card safety scheme.

Visit Yellow Card for further information .

6. How to cope with side effects of promethazine

What to do about:

feeling sleepy during the daytime – this usually wears off 12 hours after a dose. Do not drive, cycle or use tools or machinery if you're feeling this way.
nightmares – speak to your pharmacist or doctor if these do not go away or are troubling you.
feeling dizzy or unsteady on your feet, or having difficulty concentrating – stop what you're doing and sit or lie down until you feel better. If the feeling does not go away or is troubling you, do not take any more medicine and speak to a pharmacist or doctor.
headaches – make sure you rest and drink plenty of fluids. Talk to your doctor if the headaches last longer than a week or are severe.

7. Pregnancy and breastfeeding

Promethazine and pregnancy.

Promethazine can be used in pregnancy. There is no good evidence that it is harmful to your baby, but it can have side effects such as drowsiness.

For the treatment of hay fever your doctor or pharmacist may recommend a non-drowsy antihistamine ( loratadine ).

Promethazine and breastfeeding

If your doctor or health visitor says your baby is healthy, promethazine can be used during breastfeeding. If you are prescribed promethazine, it's better to take occasional doses or only for a short time.

It's not known how much promethazine passes into breast milk but it is likely to be a small amount. It has been used for many years without causing babies to have side effects. However, promethazine is a drowsy antihistamine, so may also make your baby sleepy too. It may also reduce the amount of milk you produce.

If you're breastfeeding or planning to breastfeed, talk to your doctor or pharmacist, as other medicines might be better while you're breastfeeding.

If your baby is not feeding as well as usual, seems unusually sleepy, or seems irritable, or if you have any other concerns about your baby, talk to your doctor, pharmacist, health visitor or midwife.

Non-urgent advice: Tell your doctor if you're:

trying to get pregnant
breastfeeding

Find out more about how promethazine can affect you and your baby during pregnancy on the Best Use of Medicines in Pregnancy (BUMPs) website.

8. Cautions with other medicines

Some medicines and promethazine can affect each other and increase the chance of having side effects.

Tell your pharmacist or doctor if you're taking:

a type of antidepressant called a monoamine oxidase inhibitor, such as phenelzine
a type of painkiller called an opioid, such as codeine , morphine or oxycodone
any medicine that makes you drowsy, gives you a dry mouth, or makes it difficult for you to pee – taking promethazine might make these side effects worse

If you're taking a cough or cold remedy or a painkiller containing promethazine, check carefully what the other ingredients are.

For example, promethazine often comes mixed with paracetamol . If you take 2 medicines that both contain paracetamol, there's a risk of overdose.

Ask your pharmacist for advice before you take this medicine together with any other painkillers or medicines.

Mixing promethazine with herbal remedies and supplements

There might be a problem taking some herbal remedies and supplements alongside promethazine, especially ones that cause side effects such as sleepiness, a dry mouth or making it difficult to pee.

Ask your pharmacist for advice.

Important: Medicine safety

Tell your doctor or pharmacist if you're taking any other medicines, including herbal medicines, vitamins or supplements.

9. Common questions about promethazine

Promethazine is a medicine called an antihistamine . It's classed as a drowsy (sedating) antihistamine.

When you come into contact with something you're allergic to, such as pollen or animal hair, your body produces a chemical called histamine. This can cause symptoms such as a runny nose or skin rashes.

Promethazine blocks the effects of histamine in your brain and this reduces symptoms.

It enters the brain in large quantities and this can make you feel drowsy.

Promethazine also blocks the effects of a chemical called dopamine, and this stops you feeling sick.

Promethazine blocks the effects of a natural chemical called acetylcholine.

This can help dry up a cough or runny nose, but can also cause side effects such as a dry mouth and dry nose.

Some cough and cold remedies claim to suppress your cough or stop you bringing up phlegm.

Although some people find them helpful, they're not usually recommended.

This is because there's little evidence that they're any more effective than simple home remedies and they're not suitable for everyone.

Promethazine will start to make you feel sleepy around 20 minutes after you take it and may work for up to 12 hours.

If you're taking it for a cough or cold, allergies or feeling sick (nausea), your symptoms should start to improve within 20 minutes. The medicine should work for around 4 to 6 hours.

Only take promethazine for a short time, unless your doctor says it's OK for you to take it for longer.

Speak to your pharmacist or doctor before taking promethazine for longer than the medicine leaflet recommends.

Ask them for advice if you're unsure how long you should take it for.

It's unlikely that you'll get addicted to promethazine. But it's best that you only take it for a very short time, unless your doctor tells you to take it for longer.

If you have bought a medicine containing promethazine, do not take it for longer than recommended on the packet without speaking to your pharmacist or doctor first.

If you have taken promethazine for a long time and suddenly stop taking it, it's possible you might feel dizzy, sweaty or sick, have a racing heart and have trouble sleeping.

Coming off promethazine slowly can help prevent this.

Speak to your doctor if you have taken promethazine for a long time and want to stop taking it.

Promethazine is known as a drowsy (sedating) antihistamine as it makes you sleepy.

Non-drowsy antihistamines are less likely to have this effect. These include cetirizine , fexofenadine and loratadine .

Most people prefer to take a non-drowsy antihistamine as it's less likely to interfere with their everyday routine.

You might choose to take a drowsy antihistamine, however, if you're having problems falling asleep, or if symptoms like itching or coughing are keeping you awake.

There is not enough information available to say whether one antihistamine is better than another for treating allergies.

You may need to try a few different medicines to find what works best for you. Ask your pharmacist or doctor for advice if you're unsure.

You can take 2 different antihistamines at a time, if your doctor says it's OK. If you have a severe itchy skin rash, your doctor may recommend 2 different antihistamines together for a few days.

You could take a non-drowsy antihistamine (such as cetirizine , fexofenadine or loratadine ) during the day, and a drowsy antihistamine at night if itching is making it difficult to sleep.

Do not take another drowsy antihistamine together with promethazine. It'll make you very tired and sleepy.

Other drowsy antihistamines include chlorphenamine (Piriton) and diphenhydramine (Nytol Original).

Do not take 2 antihistamines together unless you have been advised to by your doctor.

Yes. If you take it for insomnia or take it at bedtime, promethazine will help you sleep.

If you take it during the day for other conditions, such as allergies, it might make you feel sleepy during the day as well.

Yes, you can take promethazine together with some painkillers, such as paracetamol or ibuprofen .

If you take promethazine with painkillers that contain codeine (such as co-codamol or other prescription painkillers), you may feel very tired and sleepy.

It's important to check the packaging or label of your medicine carefully. This is because some promethazine products already contain a painkiller.

Do not take extra painkillers if this is the case, as there's a risk of overdose.

Speak to your pharmacist if you're not sure whether a medicine already contains a painkiller.

Do not drive a car or ride a bike if promethazine makes you sleepy during the daytime, gives you blurred vision or makes you feel dizzy, clumsy or unable to concentrate or make decisions.

This may be more likely when you first start taking promethazine, but could happen at any time (for example, when starting another medicine).

It's an offence to drive a car if your ability to drive safely is affected. It's your responsibility to decide if it's safe to drive. If you're in any doubt, do not drive.

Talk to your doctor or pharmacist if you're unsure whether it's safe for you to drive while taking promethazine. GOV.UK has more information on the law on drugs and driving .

There's no evidence to suggest that taking promethazine reduces fertility in either men or women.

But speak to a pharmacist or doctor before taking it if you're trying to get pregnant.

Promethazine does not affect any type of contraception, including the combined pill and emergency contraception .

Do not drink alcohol while you're taking promethazine.

Alcohol and promethazine together can make you sleep very deeply.

You will not be able to breathe properly and may have difficulty waking up.

You can eat normally while taking promethazine.

However, do not drink alcohol. And if you take promethazine to help you sleep, try not to have drinks that contain caffeine, like coffee, tea, cola or energy drinks. Caffeine has the opposite effect to promethazine and can stop the medicine working.

Yes, it's dangerous to take promethazine with recreational drugs. This is because it can slow or stop your heart and lungs.

Mixing promethazine and codeine in large amounts slows down the central nervous system (brain and spinal cord), which can slow breathing and heart rate.

It's even more dangerous when taken with alcohol or other drugs and has caused people to die.

Find out more about the side effects of some recreational drugs on the Frank website .

Promethazine will only help you sleep while you're taking it, so there are a number of things you can do instead to help yourself have a good night's sleep :

set regular times for going to bed and waking up
relax before bedtime – try taking a warm bath or listening to calming music
use thick curtains or blinds, an eye mask and earplugs to stop you being woken up by light and noise
avoid caffeine, cigarettes or vapes, alcohol, heavy meals and exercise for a few hours before bedtime
do not watch TV or use phones, tablets or computers before going to bed
do not nap during the day
make a list of your worries and any ideas for how to solve them before you go to bed – this can help you forget about them until the morning

If you have hay fever , it helps if you do not spend too much time outside if the pollen count is high.

Tips for when you're outside

Do not cut grass or walk on grass.
Wear wraparound sunglasses to stop pollen getting into your eyes.
Put Vaseline around your nostrils to help trap pollen.
Shower and change your clothes after you have been outside to wash off pollen.

Tips for when you're inside

Keep windows and doors shut as much as possible.
Vacuum regularly and dust with a damp cloth.
Do not keep fresh flowers in the house.
Do not smoke or be around smoke as it makes hay fever symptoms worse.

The best way to prevent any sort of allergic reaction is to avoid the substance that you're allergic to, if you can.

There are some practical steps you can follow to help prevent allergies .

Related conditions

Contact dermatitis
Motion sickness

Useful resources

Allergy UK: charity
Healthtalk: videos of real stories about sleep problems
Itchy Sneezy Wheezy: website for parents

Page last reviewed: 27 October 2021 Next review due: 27 October 2024

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Consumer medicine information

Promethazine hydrochloride

Keep track of your medicines

BRAND INFORMATION

Active ingredient

Phenergan F/C 10 mg

Phenergan F/C 25 mg

Consumer medicine information (cmi) leaflet.

Please read this leaflet carefully before you start using Phenergan.

Download CMI (PDF)
Download Large Text CMI (PDF)

Phenergan ® (fen-er-gan)

Active ingredient: Promethazine hydrochloride (PRO-meth-ar-zine HIGH-dro (h)-CLOR-ride)

Consumer Medicine Information (CMI)

This leaflet provides important information about using Phenergan. You should also speak to your doctor or pharmacist if you would like further information or if you have any concerns or questions about using Phenergan.

Where to find information in this leaflet:

1. Why am I using Phenergan? 2. What should I know before I use Phenergan? 3. What if I am taking other medicines? 4. How do I use Phenergan? 5. What should I know while using Phenergan? 6. Are there any side effects? 7. Product details

1. Why am I using Phenergan?

Phenergan contains the active ingredient promethazine hydrochloride.

Phenergan is an antihistamine used to treat a number of conditions:

allergies - allergic contact dermatitis, hives, hayfever, bites and stings
respiratory symptoms due to allergies - runny nose
nausea and vomiting - motion sickness
assists in the management of the symptoms of chicken pox and measles by acting as a sedative
for short-term use for sedation on the advice of a pharmacist or doctor - do not use for more than 7-10 days

Antihistamines help reduce allergic symptoms by preventing the effects of a substance called histamine. Histamine is produced by the body in response to foreign substances that the body is allergic to.

Your pharmacist or doctor may have recommended Phenergan for another reason.

Ask your pharmacist or doctor if you have any questions about this medicine.

2. What should I know before I use Phenergan?

Phenergan must not be used in children under 2 years of age, due to the potential for fatal respiratory depression.

Do not use Phenergan if:

you are allergic to promethazine hydrochloride, medicines of similar properties or belonging to the specific family of chemicals called phenothiazines, other phenothiazines, or any of the ingredients listed at the end of this leaflet. Always check the ingredients to make sure you can use this medicine. Some of the symptoms of an allergic reaction may include: - shortness of breath - wheezing or difficulty breathing - swelling of the face, lips, tongue or other parts of the body - rash, itching or hives on the skin If you take this medicine after the expiry date has passed, it may not work as well.
the packaging is torn or shows signs of tampering.

Any person who is unconscious or in a coma must not be treated with Phenergan.

Do not give Phenergan to newborn or premature babies.

Check with your doctor or pharmacist if you:

have allergies to: - any other medicines - any other substances, such as foods, preservatives or dyes
have or have had any medical conditions, especially the following: - kidney or liver disease - parkinson's disease - underactive thyroid gland (hypothyroidism) - tumour growing in adrenal glands (pheochromocytoma) - autoimmune disorder (myasthenia gravis) - epilepsy - cardiovascular disease/cardiac failure - blood pressure problems - low white blood cell count (agranulocytosis) - bladder problems - breathing problems - glaucoma - an eye condition - prostate problems - stomach ulcer or blockage
develop a fever or an infection to confirm if laboratory tests are required to check your blood count
plan to have surgery
take sedatives
take any medicines for any other condition
have any personal or family history of heart disease
have an irregular heartbeat

If you experience an allergic reaction, seek medical help right away.

Caution must be exercised when using Phenergan due to the risk of sedation.

If you experience fever, sore throat or any other infection, you should inform your doctor or pharmacist immediately and undergo a complete blood count. Treatment should be discontinued if any marked changed are observed in the blood count.

During treatment, you may be at risk of developing certain side effects. It is important you understand these risks and how to monitor for them. See additional information under Section 6. Are there any side effects?

Pregnancy and breastfeeding

Check with your doctor or pharmacist if you are a woman of childbearing age and not using effective contraception. Check with your doctor or pharmacist if you are pregnant, might become pregnant or think you may be pregnant.

Do not take Phenergan if you are pregnant or plan to become pregnant.

It may affect your developing baby if you take it during pregnancy. If there is a need to consider Phenergan during your pregnancy, Your pharmacist or doctor will discuss the benefits and possible risks of taking the medicine during pregnancy.

Talk to your doctor or pharmacist if you are breastfeeding or intend to breastfeed.

Do not take Phenergan if you are breastfeeding or plan to breastfeed.

It passes into the breast milk and there is a possibility that the baby may be affected.

Use in Children

Because of the risk of chocking, the tablets should be avoided in children who have difficulty swallowing tablets.

3. What if I am taking other medicines?

Tell your doctor or pharmacist if you are taking any other medicines, including any medicines, vitamins or supplements that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines may interfere with Phenergan and affect how it works

Phenergan may increase the sedative effect of some medicines. These include:

medicines used to treat depression, especially monoamine oxidase inhibitors and tricyclic antidepressants
medicines used to help you sleep or relax (sedatives and hypnotics)
opioid analgesics, medicines used to treat pain
other antihistamines
alcohol and alcohol containing medicines
medicines for the treatment of irregular heartbeats (antiarrhythmics)
medicines that help with your mood (antidepressants)
medicines used to help with mental illness (antipsychotics)
medicines to treat infections (antimicrobials)
medicines used to treat nausea and vomiting like metoclopramide
medicines used to relieve muscle spasm like carisoprodol and cyclobenzaprine
medicines used for the treatment of epilepsy or seizures
medicines used to treat acid indigestion such as magnesium, aluminium and calcium salts, oxides and hydroxides
medicines used to smooth muscle contractions in the gastrointestinal tract (antispasmodics)

These medicines may be affected by Phenergan or may affect how well it works. You may need different amounts of your medicines, or you may need to take different medicines.

Check with your doctor or pharmacist if you are not sure about what medicines, vitamins or supplements you are taking and if these affect Phenergan.

4. How do I use Phenergan?

How much to take.

Follow the instructions provided with the medicine. If you do not understand the instructions on the carton or the label, ask your pharmacist or doctor for help.
Follow all directions given to you by your pharmacist or doctor carefully. They may differ from the information contained in this leaflet.
Use this drug only as recommended.
Do not exceed the recommended dosage. There have been case reports of promethazine abuse.
Phenergan tablets are recommended for adults and children over 6 years of age.
Phenergan elixir is recommended for children 2-5 years of age.
It is recommended that the lowest effective dose of Phenergan be used in children 2 years of age or older.

Allergic Disorder

Adults: One to three 25mg tablets as a single dose at night, or one to two 10mg tablets, two to three times daily.
Children 6-12 years: One to two 10mg tablets, or 10 to 25mL of the elixir as a single dose at night, or one 10mg tablet, or 10mL of the elixir, two to three times daily.
Children 2-5 years: 5-15mL of elixir as a single dose at night, or 5mL of elixir, two to three times daily.
For short term use on the advice of a pharmacist or doctor.
Adults: One to three 25mg tablets as a single dose at night.
Children 6-12 years: One to two 10mg tablets, or 10 to 25mL of the elixir, as a single dose at night.
Children 2-5 years: 5-15mL of elixir as a single dose at night.

Travel Sickness

Adults: One 25mg tablet.
Children 6-12 years: One 10mg tablet or 10mL of the elixir.
Children 2-5 years: 5mL of elixir.
To be taken the night before travel and repeated after 6 to 8 hours on the following day if required.

Nausea and Vomiting

Adults: One 25mg tablet every 4 to 6 hours to a maximum daily dose of four 25mg tablets.
Children 6-12 years: One 10mg tablet or 10mL of the elixir, every 4 to 6 hours to a maximum daily dose of two 10mg tablets or 25mL of the elixir.
Children 2-5 years: 5mL of elixir every 4 to 6 hours to a maximum daily dose of 15mL.

Use in the Elderly

If you are over 65 years of age, talk to you pharmacist or doctor about how much to take.
Elderly patients are more likely to have side effects from taking these medicines.

How to take Phenergan

Swallow Phenergan tablets whole with a full glass of water.
Measure out the amount of elixir to be taken.

How long to take it

Phenergan should not usually be taken for more than 10 days in a row. If your symptoms persist, see your pharmacist or doctor for advice.

If you forget to take it

If you are taking Phenergan for an allergic disorder and you forget to take your bedtime dose, you may need to take your dose in two or three smaller doses during the following day. Check with your pharmacist or doctor.

If you are taking Phenergan for travel sickness or nausea and vomiting, take your dose as soon as you remember.

If you are taking Phenergan for sedation, take your dose as soon as you remember. Be careful because you may still be affected in the morning.

Do not take a double dose to make up for the dose that you missed. This may be harmful.

If you are not sure what to do, ask your pharmacist or doctor.

If you have trouble remembering to take your medicine, ask your pharmacist for some hints.

If you use too much Phenergan (overdose)

If you think that you have used too much Phenergan, you may need urgent medical attention.

You should immediately:

phone the Poisons Information Centre ( by calling 13 11 26 in Australia or 0800 764 766 in New Zealand ), or
contact your doctor, or
go to the Emergency Department at your nearest hospital.

You should do this even if there are no signs of discomfort or poisoning.

If you take too much Phenergan, you may experience:

convulsions and/or tremors
difficulty breathing
unconsciousness
acute anxiety
hallucinations
heart palpitations, chest pain and/or rapid pulse
cold sweats
over - excitement
shaky and unsteady movements

5. What should I know while using Phenergan?

Things you should do.

Remind any doctor, dentist or pharmacist you visit that you are using Phenergan.

Phenergan may cause your skin to be more sensitive to the sun. You should protect your skin from exposure to bright sunlight.

If you are about to be started on any new medicine, tell your pharmacist or doctor that you are taking Phenergan.

If you plan to have surgery that needs a general anaesthetic, tell your doctor or dentist that you are taking this medicine.

If you become pregnant while you are taking this medicine, stop taking it and tell your doctor immediately.

Talk to your pharmacist or doctor if your symptoms do not improve.

Your pharmacist or doctor will assess your condition and decide if you should continue to take the medicine.

Things you should not do

Do not give Phenergan to anyone else, even if they have the same condition as you.
Do not take Phenergan to treat any other complaints unless your pharmacist or doctor tells you to.
Do not take more than the recommended dose unless your pharmacist or doctor tells you to.

Things to be careful of

Phenergan is a known sedative and may cause drowsiness in some people.
If you have a single dose at bedtime, you may still be affected in the morning.
Children and the elderly are especially sensitive to the effects of antihistamines.

Neuroleptic malignant syndrome

A very serious and sometimes deadly health problem called neuroleptic malignant syndrome (NMS) may happen. Stop treatment and call your doctor right away if you have high fever, muscle cramps or stiffness, dizziness, very bad headache, fast heartbeat, confusion, agitation, hallucinations, or are sweating a lot.

Driving or using machines

Phenergan can cause drowsiness, dizziness and blurred vision. Make sure you know how you react to Phenergan before you drive a car, operate machinery, or do anything else that could be dangerous if you experience drowsiness, dizziness and blurred vision. If this occurs do not drive or operate machinery.

Be careful before you drive or use any machines or tools until you know how Phenergan affects you.

Phenergan may affect your ability to drive a car or operate machinery or do anything else that could be dangerous if you are drowsy, dizzy or experience blurred vision. If this occurs do not drive or operate machinery.

Drinking alcohol

Tell your doctor or pharmacist if you drink alcohol.

Do not drink alcohol while taking Phenergan.

The sedation effects of alcohol may be increased.

Looking after your medicine

Keep your medicine in the pack until it is time to take it.
If you take your medicine out of the pack it will not keep as well.
Store Phenergan tablets below 30°C.
Store Phenergan elixir below 25°C.

Follow the instructions in the carton on how to take care of your medicine properly.

Store it in a cool dry place away from moisture, heat or sunlight; for example, do not store it:

in the bathroom or near a sink, or
in the car or on window sills.

Keep it where young children cannot reach it, in a locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines

Getting rid of any unwanted medicine

If you no longer need to use this medicine or it is out of date, take it to any pharmacy for safe disposal.

Do not use this medicine after the expiry date.

6. Are there any side effects?

All medicines can have side effects. If you do experience any side effects, most of them are minor and temporary. However, some side effects may need medical attention.

See the information below and, if you need to, ask your doctor or pharmacist if you have any further questions.

Less serious side effects

These are mild side effects of the medicine and are short-lived.

Serious/rare side effects

The above list includes serious side effects that may require medical attention. Serious side effects are rare.

The above list includes very serious side effects. You may need urgent medical attention or hospitalisation. These side effects are very rare.

Tell your doctor or pharmacist if you notice anything else that may be making you feel unwell.

Other side effects not listed here may occur in some people.

Reporting side effects

After you have received medical advice for any side effects you experience, you can report side effects to the Therapeutic Goods Administration online at www.tga.gov.au/reporting-problems or Medsafe in New Zealand www.medsafe.govt.nz/safety/report-a-problem.asp#Medicine . By reporting side effects, you can help provide more information on the safety of this medicine.

7. Product details

This medicine is available over-the-counter without a doctor's prescription.

What Phenergan Tablets contain

Do not take this medicine if you are allergic to any of these ingredients.

What Phenergan Elixir contains

What phenergan looks like.

Phenergan Tablets are available in two strengths:

10mg - circular, film-coated biconvex tablets with bevelled edges, pale blue in colour, one face impressed 'PN' above ‘10', the reverse face plain.
25mg - circular, film-coated biconvex tablets with bevelled edges, pale blue in colour, one face impressed 'PN' above '25', the reverse face plain.

Both tablet strengths are available in blister packs of 50 tablets and 25 tablets (New Zealand only).

Phenergan Elixir is a clear, bright, golden, syrupy liquid. Phenergan elixir is available in a 100mL bottle

Australian Registration Numbers

Phenergan 10mg tablets AUST R 80159

Phenergan 25mg tablets AUST R 80160

Phenergan Elixir 1mg/mL AUST R 61576

Who distributes Phenergan

Phenergan Tablets and Elixir are supplied in Australia by:

Sanofi Consumer Healthcare 87 Yarraman Place Virginia Australia Toll Free Number (medical information) 1800 818 806

This leaflet was prepared in May 2022.

phenergan-ccdsv45cmiv13-27may22

Published by MIMS July 2022

1 Name of Medicine

Promethazine hydrochloride.

2 Qualitative and Quantitative Composition

Excipients with known effect., 3 pharmaceutical form, 4 clinical particulars, 4.1 therapeutic indications, upper respiratory tract., nausea and vomiting., 4.2 dose and method of administration, children 6-12 years., children 2-5 years., 4.3 contraindications.

Promethazine is contraindicated for use in patients with a history of hypersensitivity to the drug substance, substances of similar chemical structure, other phenothiazines or hypersensitivity to the other ingredients in the formulation. Phenergan sugar free (orange flavour) elixir should not be given to patients with allergies to sodium metabisulfite, sodium sulfite or sodium benzoate. Promethazine is contraindicated for use in: children under 2 years of age because of the potential for fatal respiratory depression. Post-marketing cases of respiratory depression, including fatalities, have been reported with the use of promethazine in paediatric patients less than 2 years of age. A wide range of weight-based doses of Phenergan have resulted in respiratory depression in these patients (see Section 4.4 Special Warnings and Precautions for Use); lactating women; patients taking monoamine oxidase inhibitors (MAOIs) up to 14 days previously (see Section 4.5 Interactions with Other Medicines and Other Forms of Interactions); jaundice induced by other phenothiazine derivatives; patients in coma or suffering from CNS depression of any cause or who have received high doses of other CNS depressants. See Section 4.5 Interactions with Other Medicines and Other Forms of Interactions for additional information.

4.4 Special Warnings and Precautions for Use

Hypertensive crisis., use in hepatic impairment., use in renal impairment., use in the elderly., paediatric use., effects on laboratory tests., 4.5 interactions with other medicines and other forms of interactions, cytochrome p450 2d6 metabolism., seizure threshold-lowering drugs., gastro-intestinal agents that are not absorbed (magnesium, aluminium and calcium salts, oxides and hydroxides)., drugs with anticholinergic properties., 4.6 fertility, pregnancy and lactation, effects on fertility., 4.7 effects on ability to drive and use machines.

Promethazine considerably affects the ability to drive a vehicle and operate machines. Promethazine may cause drowsiness, dizziness and blurred vision and can considerably affect the ability of driving a vehicle and operating machines. Drowsiness may continue the following day. Those affected should not drive or operate machinery.

4.8 Adverse Effects (Undesirable Effects)

Cns effects., anticholinergic effects., more common reactions., gastrointestinal disorders., nervous system disorders., eye disorders., less common reactions., cardiovascular., skin and subcutaneous tissue disorders., haematological., respiratory., reactions with frequency unknown., hepatobiliary disorders., renal and urinary disorders., immune system disorders., metabolism and nutrition disorders., blood and lymphatic system disorders., psychiatric disorders., cardiac disorders., respiratory, thoracic and mediastinal disorders., vascular disorders., general disorders and administration site conditions., severe or life threatening reactions., reporting suspected adverse effects., 4.9 overdose, 5 pharmacological properties, 5.1 pharmacodynamic properties, mechanism of action., clinical trials., 5.2 pharmacokinetic properties, absorption., distribution., metabolism., 5.3 preclinical safety data, genotoxicity., carcinogenicity., 6 pharmaceutical particulars, 6.1 list of excipients.

Phenergan Elixir contains sodium benzoate, sodium sulfite, sodium metabisulfite, maltitol solution, acesulfame potassium, sodium citrate dihydrate, citric acid monohydrate, ascorbic acid, caramel, purified water and orange juice flavour 510844E. Phenergan Tablets contain lactose monohydrate, maize starch, povidone, magnesium stearate, hypromellose, macrogol 200 and opaspray blue M-1-4210A.

6.2 Incompatibilities

Incompatibilities were either not assessed or not identified as part of the registration of this medicine.

6.3 Shelf Life

In Australia, information on the shelf life can be found on the public summary of the Australian Register of Therapeutic Goods (ARTG). The expiry date can be found on the packaging.

6.4 Special Precautions for Storage

6.5 nature and contents of container, 6.6 special precautions for disposal.

In Australia, any unused medicine or waste material should be disposed of by taking to your local pharmacy.

6.7 Physicochemical Properties

Chemical structure., cas number., 7 medicine schedule (poisons standard).

Elixir, Tablets: Pharmacist Only Medicine (Schedule 3).

Summary Table of Changes

Date published: 01 july 2022.

Reasonable care is taken to provide accurate information at the time of creation. This information is not intended as a substitute for medical advice and should not be exclusively relied on to manage or diagnose a medical condition. NPS MedicineWise disclaims all liability (including for negligence) for any loss, damage or injury resulting from reliance on or use of this information. Read our full disclaimer . This website uses cookies. Read our privacy policy .

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Patient info
» Patient leaflets
» PHENERGAN 10 MG TABLETS - patient leaflet, side effects, dosage

PHENERGAN 10 MG TABLETS - patient leaflet, side effects, dosage

R06AD02 promethazine

Dostupné balení:

Sources: Original (products.mhra.gov.uk)

Patient leaflet - PHENERGAN 10 MG TABLETS

Phenergan 10 mg

promethazine hydrochloride

Is this leaflet hard to see or read? Phone 0800 035 2525 for help

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

Always take this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you.

Keep this leaflet. You may need to read it again
Ask your pharmacist if you need more information or advice
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4 .
You must talk to a doctor if you do not feel better or if you feel worse after 7 days.

1. What Phenergan Tablets are and what they are used for

2. What you need to know before you take Phenergan Tablets

3. How to take Phenergan Tablets

4. Possible side effects

5. How to store Phenergan Tablets

6. Contents of the pack and other information

What Phenergan Tablets are used for

Phenergan Tablets are used to treat the following conditions:

For short term use: to treat adults with difficulty sleeping (insomnia)
To treat allergic conditions such as hay fever or rashes (like nettle rash or hives)
To treat or stop you feeling sick (nausea) or being sick (vomiting) such as travel sickness
For short term use: as a sedative for

children aged 5 years and above

2. what you need to know before you take phenergan tablets

Qis do not take this medicine if:.

X The person taking the medicine is under

5 years of age

X You are allergic (hypersensitive) to promethazine hydrochloride or any of the other ingredients of Phenergan Tablets (listed in Section 6 below)

X The signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue.

X You are taking a medicine for depression called a monoamine oxidase inhibitor (MAOI). Also do not take Phenergan Tablets if you have stopped taking one of these MAOI medicines within the last 14 days. If you are not sure ask your doctor or pharmacist (see “Taking other medicines” section below)

X The person is unconscious (in a coma) or suffers from severe dizziness, drowsiness or headache

Do not take this medicine if any of the above applies to you. If you are not sure, talk to your doctor or pharmacist before taking Phenergan Tablets.

1. What Phenergan Tablets are and what they are used for

Warnings and precautions

Phenergan Tablets contain a medicine called promethazine hydrochloride. This belongs to a group of medicines called phenothiazines. It works by blocking a natural substance (histamine) that your body makes during an allergic reaction. It also works directly on the brain to help you feel more relaxed.

Check with your doctor or pharmacist

Before taking your medicine if.

You have difficulty breathing, wheezing,

tightness in the chest (asthma) or an

infection in your lungs (bronchitis)

You have epilepsy You have any serious heart problems

11503107–08

A You have liver or kidney problems

A You have a stomach blockage or difficulty passing water (urine)

A You have hearing problems

A You have increased pressure in the eye (narrow angle glaucoma)

A You have had something called Reye’s Syndrome or possible Reye’s Syndrome signs include being sick and confused following a viral illness

If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Phenergan Tablets.

SS.hermed^andPhenerganTab.

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines you can buy without prescription, including herbal medicines. This is because Phenergan Tablets can affect the way some medicines work. Also some medicines can affect the way Phenergan Tablets work.

Do not take this medicine, and tell your doctor, if you are taking or have taken the following in the last 2 weeks:

Some medicines for depression called monoamine oxidase inhibitors (MAOIs). If you are not sure ask your doctor or pharmacist

Tell your doctor or pharmacist if you are taking any of the following:

Anticholinergic medicines – includes some medicines used for irritable bowel syndrome, asthma or weak bladder. These can increase the risk of dizziness, dry mouth and blurred eyesight
Medicines for depression (such as amitriptyline)
Medicines to help you to sleep or feel more relaxed (such as diazepam or zolpidem)
Medicines such as aspirin (for arthritis and pain in your joints). Phenergan Tablets may hide the side effects of these medicines

Phenergan Tablets with food and drink Do not drink alcohol while you are taking Phenergan Tablets. This is because it can affect the way the medicine works.

Pregnancy and breast-feeding

Talk to your doctor or pharmacist before taking this medicine if you are pregnant, might become pregnant, or think you may be pregnant. Phenergan Tablets should not be taken 2 weeks before birth.

You should not take Phenergan Tablets if you are breast-feeding. This is because small amounts may pass into mothers’ milk. This can be harmful to your baby.

If you are breast-feeding or planning to breast-feed, talk to your doctor or pharmacist before taking any medicine.

I Driving and using machines

You may feel drowsy or sleepy after taking this medicine or in the morning after taking this medicine. If this happens, do not drive or use any tools or machines.

Phenergan Tablets contains lactose:

If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

3.How to take Phenergan Tablets

Always use this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

The amount you need to take depends on the reason you are taking Phenergan Tablets. The following information will help you to decide how much you need to take.

Taking this medicine

Take this medicine by mouth
Do not take for longer than 7 days. If your symptoms worsen or do not improve after 7 days talk to your doctor or pharmacist
If you feel the effect of your medicine is too weak or too strong, do not change the dose yourself, but ask your doctor

How much to take

The recommended dose is:

For allergies (such as hay fever, rashes and hives)

Children 2–5 years:

Phenergan Elixir should be given in this age group

Children 5–10 years:

A single dose of either one or two tablets (10mg or 20mg) given at night or one tablet (10mg) given twice a day
DO NOT give more than two tablets (20mg) each day

Children over 10 years and adults (including the elderly):

Start with one tablet (10mg) twice a day
This may be increased to a maximum of two tablets (20mg) three times a day

For treatment and prevention of feeling sick or being sick (such as travel sickness)

A single tablet to be taken the night before the journey
This may be repeated after 6–8 hours if necessary
Two tablets (20mg) to be taken the night before the journey

As a short term paediatric sedative and for short term treatment of insomnia in adults

Two tablets (20mg) given as a single dose at night time

Children over 10 years and adults

(including the elderly):

Two to five tablets (20mg to 50mg) as a single dose at night time

Use this medicine only as recommended. Do not exceed the recommended dose.

Exposure to sunlight

Phenergan Tablets can make your skin more sensitive to sunlight. Keep out of direct sunlight while taking this medicine.

If you take more Phenergan Tablets than you should

If you or your child takes more Phenergan Tablets than you should, tell a doctor or go to a hospital casualty department straight away. Take the medicine pack with you.

This is so the doctor knows what you or your child has taken.

The following effects may happen:

In children: Excitation, moving unsteadily or stumbling, uncontrolled writhing movements especially of the hands or feet, hallucinations, fits (seizures), loss of consciousness, uneven heart beat and breathing difficulties.

In adults: Feeling sleepy or drowsy, fits, loss of consciousness, uneven heart beat and breathing difficulties.

If you forget to take Phenergan Tablets Do not take a double dose to make up for a forgotten dose

If you are taking Phenergan Tablets for an allergic condition – take your medicine as soon as you remember, then carry on as before
If you are taking Phenergan Tablets for sedation or sleeping problems – miss that dose and take the next evening’s dose as usual

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Taking Phenergan Tablets may affect the results of certain tests. These include some pregnancy tests and skin tests. Phenergan Tablets should not be taken at least 3 days before the start of a skin test.

4. possible side effects

Like all medicines, Phenergan Tablets can cause side effects, although not everybody gets them.

Stop taking Phenergan Tablets and see a doctor or go to a hospital straight away if you notice any of the following side effects: An allergic reaction. The signs may include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue
Liver problems that may cause the eyes or skin to go yellow (jaundice)
Muscle stiffness or shaking
Being unable to control some muscles in your head or face
You notice unusual movements of the tongue, facial muscle spasms, rolling eyes and trembling
Very fast, uneven or forceful heartbeat (palpitations)
Irregular heartbeat
Tiredness which lasts for a long time. This may be due to a blood problem called anaemia
Over-active behaviour in children

Tell your doctor or pharmacist if any of the following side effects get serious or lasts longer than a few days. Also tell them if you notice any side effects not listed in this leaflet.

Dry mouth, blurred vision or you cannot pass water (urine)
Feeling drowsy or sleepy, tiredness, disorientation, having nightmares, headaches, feeling restless
Loss of appetite (anorexia), indigestion
Feeling dizzy, lightheaded, faint (hypotension) Feeling confused, especially in elderly people Being more sensitive to the sun than usual.

If this happens keep out of direct sunlight and do not use sun lamps

Unpleasant sensation or an overwhelming urge to move the legs (also called Restless Legs Syndrome).

Reporting of Side Effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at:. gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

By reporting side effects you can help provide more information on the safety of this medicine.

5. how to store phenergan tablets

Keep this medicine out of the sight and reach of children
Do not take Phenergan Tablets after the expiry date which is stated on the carton and blister pack after EXP. The expiry date refers to the last day of that month
Store below 30°C
Store in the original carton in order to protect from light

Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

6. contents of the pack and other information

What phenergan tablets contains..

Each tablet contains 10mg of the active substance, promethazine hydrochloride
The other ingredients are lactose, maize starch, povidone, magnesium stearate, polyethylene glycol, Opaspray (contains titanium dioxide-E171, hypromellose-E464 and indigo carmine aluminium lake blue-E132) and hypromellose

What Phenergan Tablets look like and contents of the pack

A pale blue film coated tablet marked PN 10 on one side. The tablets are available in blister packs of 56.

Marketing Authorisation Holder and Manufacturer

Marketing Authorisation Holder

410 Thames Valley Park Drive Reading

Tel: 0800 035 2525

Manufacturer

FAMAR HEALTH CARE SERVICES MADRID, S.A.U.

Avda. Leganes, 62

Alcorcon 28923

This leaflet does not contain all the information about your medicine. If you have any questions or are not sure about anything, ask your doctor or pharmacist.

This leaflet was last revised in 09/2020

Preventing motion sickness in children

Linda v graudins.

Aust Prescr 2009;32:61-3
1 June 2009
DOI: 10.18773/austprescr.2009.032
antihistamines
Motion sickness
paediatric care
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Motion sickness is a normal response to abnormal stimuli. The peak incidence occurs in children under 12 years, but it is uncommon in infants. As this condition has central and vestibular origins, centrally acting drugs may be useful. There is no evidence to support the efficacy or safety of drugs for children less than two years old. Potentially effective drugs in older children include hyoscine and antihistamines. Both are associated with anticholinergic adverse effects. Ginger and acupuncture bands may be used, but have only been evaluated in adults.

Introduction

Motion sickness is a common condition, with about 30% of the general population suffering some kind of symptoms during a voyage and 5% suffering heavily. There are no specific statistics for incidence in children. Children under two years old are highly resistant to motion sickness, as they are often supine and do not use visual cues for spatial orientation. Susceptibility peaks around 10–12 years of age. Motion sickness in children occurs mainly during car, train and air travel, but also may occur on amusement park rides and during virtual reality immersion. 1

There are simple preventative measures which may reduce the likelihood of travel sickness ( see box ). If these fail, pharmacological therapies may be tried in children older than two years.

Rationale for pharmacological management

Conflicting signals from vestibular, vision and proprioception systems produce symptoms of pallor and cold sweat, which usually precede epigastric discomfort, nausea and emesis. Ataxia and dizziness may be a feature in younger children. Prolonged motion sickness may cause drowsiness, apathy and even a feeling of impending doom. Cortical centres may also be involved, explaining the effect of anticipatory nausea before travelling.

The first mention of a drug for motion sickness was in the 1860s in the Lancet, when tincture of belladonna was recommended.

Promethazine was approved in the 1950s, but it is only since the 1970s that cholinergic stimulation has been the postulated basis of motion sickness. Primarily, antihistamines and anticholinergics are used. These drugs act on vestibular receptors and nuclei, the cerebellum and the vomiting centre.

Treatment options (see ref. 2)

The following general points should be considered when managing children who are prone to motion sickness:

As motion sickness induces gastric stasis, it slows drug absorption, so preventing symptoms from occurring is more effective than trying to treat them after symptom onset.
There are no controlled studies of anti-motion sickness drugs in young children. Clinical use is based on pharmacology principles and extrapolation of data from adult studies.
While most anti-motion sickness medicines cause drowsiness, they should not be used as sedatives for air travel, as excessive sedation combined with lower oxygen partial pressure can be potentially dangerous for some children. 3
All anti-motion sickness medications are also effective antiemetics.

Box Simple ways to prevent travel sickness 2 , 4

Efficacy and safety, hyoscine hydrobromide (scopolamine).

A systematic review of 14 controlled trials involving hyoscine found it to be more effective than placebo, but not superior to antihistamines. Studies were predominantly in adult males. Hyoscine is less sedating than antihistamines, but has more anticholinergic effects. 5

Antihistamines

Given their lack of efficacy and potential to cause serious adverse drug reactions, such as hallucinations, agitation and breathing difficulties, antihistamines (H1 receptor antagonists) should not be used to prevent or treat motion sickness in children less than two years of age and should be used with caution in older children. Fatalities have been reported when over-the-counter products containing antihistamines were given to young children to treat coughs and colds. 6 There are no specific paediatric data for these drugs in motion sickness and dosing has been extrapolated from studies done in adults. In Australia, sedating antihistamines have recently become prescription-only for children less than two years of age. 7 This is now in line with New Zealand regulations. These drugs cause anticholinergic adverse effects of excitability, agitation, drowsiness, dry mouth, blurred vision and constipation. They should be avoided in children with seizure disorders.

Promethazine theoclate, promethazine hydrochloride and dimenhydrinate are approved in Australia for prevention and treatment of motion sickness. Timing varies, but they should be given at least 30 minutes before travelling. While diphenhydramine is used overseas for motion sickness prophylaxis in children, this is not an approved indication in Australia.

Non-sedating antihistamines, such as loratadine and cetirizine, penetrate poorly into the central nervous system and are not effective against motion sickness.

Complementary alternatives

Studies in adults using acupuncture wristbands, which activate the P6 Neiguan acupuncture point (5 cm above the wrist), show relief of nausea in pregnancy and after chemotherapy, but evidence for efficacy in motion sickness is contradictory. There are no studies in children, although wristbands are marketed for this age group.

Placebos have provided benefit in up to 45% of cases in controlled studies. 8

Ginger (Zingiber officinale) has been used for centuries for its antiemetic properties. 9 Studies have shown reduced nausea in patients with hyperemesis gravidarum, postoperative nausea and vomiting and in a study using a revolving chair simulating motion sickness. There has not been more than anecdotal evidence of the efficacy of ginger for prevention and treatment of motion sickness in children. Ginger inhibits thromboxane synthetase and in high doses may potentiate the effects of anticoagulants, for example aspirin, heparin and warfarin. It may cause mild gastrointestinal upset.

A study using prism glasses from the 1980s reported a significant decrease in vomiting episodes in children (n=201) prone to motion sickness. The prism glasses were thought to decrease the discrepancy between visual and vestibular cues and thus to reduce the negative effects of vertigo. 10

Treatments available overseas 2 , 11

Hyoscine as a transdermal patch is available overseas for children older than 10 years. These patches have been shown to provide effective motion sickness prophylaxis for 72 hours, but have not been evaluated in younger children. Toxic psychosis has been reported in children using this treatment.

Cinnarizine and its derivative flunarizine are piperazine antihistamines with vasodilating actions of calcium channel blockers. The only study of anti-motion sickness drugs specifically in children was in an open study with cinnarizine. It was rated by participants (n=79, mean age 8.4 years) to be effective in preventing car sickness, with a low level of adverse effects. 12

Motion sickness is a common condition, with many marketed remedies for children. Few have undergone controlled trials and even fewer have been scientifically tested specifically in children. The recent changes in labelling and restriction of access of antihistamines for children younger than two years of age highlight the importance of continual review of medicines used in children.

Acknowledgement: Dr Madlen Gazarian, Paediatric Clinical Pharmacologist and Head, Paediatric Therapeutics Program, University of New South Wales and Sydney Children's Hospital, for helpful comments about the manuscript.

Self-test questions

The following statements are either true or false.

1. Children travelling by plane should not be sedated with antihistamines.

2. To prevent motion sickness, medication should be given at least 30 minutes before the start of a journey.

Answers to self-test questions

Oosterveld WJ. Motion sickness. J Travel Med1995;2:182-5.
Gordon CR, Shupak A. Prevention and treatment of motion sickness in children. CNS Drugs 1999;12:369-81.
Air travel and children's health issues. Paediatr Child Health 2007;12:45-59.www.cps.ca/English/statements/CP/cp07-01.htm [cited 2009 May 5]
Centers for Disease Control. Travelers' health:Yellow book. Chapter 6: Motion sickness. Philadelphia (PA): CDC; 2008. wwwn.cdc.gov/travel/yellow Book Ch6-Motion Sickness [cited 2009 May 5]
Spinks AB, Wasiak J, Villanueva EV, Bernath V. Scopolamine (hyoscine) for preventing and treating motion sickness. Cochrane Database of Systematic Reviews 2007, Issue 3. Art. No.: CD002851. DOI: 10.1002/14651858. CD002851.pub3.
FDA Public Health Advisory. Nonprescription cough and cold medicine use in children. 2008 updated Oct 10. www.fda.gov/cder/drug/advisory/cough_cold_2008.htm[cited 2009 May 5]
Department of Health and Ageing. TGA announcement regarding the use of cough and cold medicines in children. 2008 Apr 17. www.tga.gov.au/media/2008/080409cold.htm[cited 2009 May 5]
Mc Intosh IB. Motion sickness \u2013 questions and answers. J Travel Med 1998;5:89-91.
White B. Ginger: an overview. Am Fam Physician 2007;75:1689-91.www.aafp.org/afp/20070601/1689.htm[cited 2009 May 5]
Vente PE, Bos JE, de Wit G. Motion sickness amelioration induced by prism spectacles. Brain Res Bull 1988;47:503-5.
Drugs used in nausea and vertigo. British National Formulary for children. London: BMJ Publishing, RPS Publishing, and RCPCH Publications Ltd; 2008.
Macnair AL. Cinnarizine in the prophylaxis of car sickness in children. Curr Med Res Opin 1983;8:451-5.

Medication Safety and QUM Pharmacist, Paediatric Therapeutics Program, University of New South Wales and Sydney Children's Hospital, Sydney

About Australian Prescriber

Date published: 01 June 2009

Promethazine For Children Under 2 Years Old

In our latest question and answer, the pharmacist discusses the use of promethazine in children under 2 years old.

Vijay asked

What is the allowed dosage of promethazine for 19-month-old child?

At a glance

Promethazine is contraindicated in children less than 2 years old due to the risk of respiratory depression.

Vector Of Medicine Syrup Bottle WIth Spoon WIth Text - Promethazine For Children

The use of promethazine in children under two years of age isn't approved by the FDA (Food and Drug Administration). It used to be prescribed to infants and children under two years old but was linked to respiratory depression and SIDS (sudden infant death syndrome). [1]

Promethazine In Children

Current guidelines on the use of promethazine state that use in children under two years old is contraindicated and the prescribing information for the drug contains a black box warning regarding the risk of respiratory depression in this age group.

Per the prescribing information: [2]

Phenergan [promethazine] should not be used in pediatric patients less than 2 years of age because of the potential for fatal respiratory depression. Postmarketing cases of respiratory depression, including fatalities, have been reported with the use of Phenergan [promethazine] in pediatric patients less than 2 years of age. Phenergan Prescribing Informaton

Dosing in children over two years old is weight-based , and depends on what it is being used for.

For the prevention of motion sickness: [3]

0.25 to 0.5 mg/kg/dose given 30 minutes to 2 hours before travel and every six to twelve hours as needed. The maximum amount per dose is 25 mg. Most sources recommend using the lowest dose possible and should be reserved only for severe cases of motion sickness.

For the treatment of postoperative nausea/vomiting: [4]

0.25 to 1 mg/kg/dose every four to six hours as needed, with a maximum dose of 25 mg.

Additional Information

In your question, you inquired about the use of promethazine in a 19-month-old child.

As described above, it is not indicated by the FDA to be used in that age group due to the risk of respiratory depression.

Having said that, everyone's medical situation is different and there certainly could be extenuating circumstances that make prescribing promethazine ' off-label ' the most appropriate therapy choice for your child.

Be sure to speak with your doctor about the risks and benefits of this particular therapy.

^ Inappropriate prescribing of promethazine in infants. PubMed
^ Promethazine Prescribing Information
^ Travel Medicine, 3rd Edition . ScienceDirect
^ Elsevier ClinicalKey: Promethazine Monograph

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Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of the Q+A website PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours!

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Experts say you should never do this on a flight

By: Author Alison Godfrey

Posted on July 16, 2019

Doctors issue warning: phenergan kids side-effects are real.

A long haul flight with a toddler is rarely easy. Once they start walking, toddlers have an insatiable curiosity that can not be confined to a small seat for 20 hours. The in-flight entertainment system is no help for a toddler with a desire to walk and walk constantly. Then imagine you have two children, or three or four to keep busy.

Look on any online travel advice forum and you will find parents of toddlers desperate for advice. “What can I take to keep him busy on the plane?”. “How do I stop them from walking the aisles?” “How do I get them to sleep?”

The biggest question many parents of toddlers ask is: “Is it safe to drug them?”.

Could you handle twins on a long haul flight?

The answer, according to medical experts is NO.

“ Sedative drugs, including antihistamines such as Phenergan, are unpredictable and we do not recommend them for children on plane trips, car trips,” a spokesperson for the Children’s Hospital at Westmead told Family Travel.

“These drugs often have side effects that can trigger the exact opposite of sedation and can lead to hallucinations.

“These antihistamine medications should only ever be used for allergies.”

Phenergan is th e most common sedative drug used by parents to calm kids on flights is . Many people also use Phenergan for flight anxiety. In 2015, a GIO survey also found one in five NSW families have their children medication to keep them quiet on long road trips.

Experts say the drug should not be used on children under two. In 2006 the US Food and Drug Administration (FDA) identified links between Phenergan and 22 cases of respiratory depression among infants. Seven of those cases were fatal. This is why the label states “caution should be applied when the medicine is given to children 2 years of age and older”.

Backlash against mum who did it

In 2018 Shona Sibary told UK chat show This Morning that she regularly gives Phenergan to her four children to get through long-haul flights.

“I am not embarrassed, I just don’t think it is fair when somebody else who has paid an absolute fortune for an economy flight seat why should they put up with a screaming child for 15 hours?” Shona told This Morning.

The backlash online was fierce.

“Drug your child on a flight to help the passengers around you… Are you kidding me?!?!? I’ve been taking my kids on flights since they were 6 months and would never dream of drugging/sedating them for the sake of other passengers,” wrote one viewer on Facebook.

Clearly, the issue sparks fierce debate and parents can make up their own mind. But the experts are adamant the risks of using Phenergan for a flight with kids are too high.

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Travel allows you to get outside your bubble. It makes you realise there are other ways to do things, and that’s OK. Plus, I am a huge fan of skiing and for the best powder – you need to head overseas.

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COMMENTS

Phenergan (Promethazine): Medication against travel sickness
2024. The unpleasant symptoms of travel sickness (aeroplane, ship, car or bus) can be prevented by a drug called Phenergan. Its active ingredient is called Promethazine. It is an antihistamine that helps to prevent the effects of histamine in the body, helping you to avoid many unpleasant symptoms associated with travelling.
Phenergan Dosage Guide
The average effective dose of Phenergan for the active therapy of nausea and vomiting in children or adults is 25 mg. When oral medication cannot be tolerated, the dose should be given parenterally (cf. Phenergan Injection) or by rectal suppository. 12.5- to 25-mg doses may be repeated, as necessary, at 4- to 6-hour intervals.
Promethazine (Oral Route) Proper Use
The dose is usually 6.25 to 12.5 mg three times a day; or 25 mg at bedtime as needed. Children younger than 2 years of age—Use and dose must be determined by your doctor . For prevention of motion sickness: Adults and teenagers—25 mg twice daily; this initial dose should be taken one-half to one hour before traveling.
Promethazine for Kids: Uses, Dosages, Warnings
Dosage. Promethazine can be given as an oral tablet, liquid medication, suppository, or injection. Dosing is based on body weight. It comes in 12.5 milligrams (mg), 25 mg, or 50 mg tablets. In children older than 2 years of age, the recommended dose is 0.5 mg of promethazine per pound of body weight.
Promethazine For Children: Dosage And Side Effects
Promethazine is an antihistamine drug to manage allergies, motion sickness, nausea, vomiting, sedation, etc. The FDA recommends against using promethazine for children under two years and suggests cautious use for children above two years. Drowsiness, dry mouth, nightmares, blurred vision, etc., are a few side effects of promethazine in children.
Motion Sickness (Travel Sickness): Prevention and Treatment
Hyoscine is usually the most effective medicine for motion sickness. It is also known as scopolamine. It works by preventing the confusing nerve messages going to your brain. There are several brands of medicines which contain hyoscine - they also come in a soluble form for children.
Phenergan Uses, Dosage & Side Effects
Phenergan can cause severe breathing problems or death in very young children. Carefully follow your doctor's instructions when giving this medicine to a child of any age. ... For motion sickness, Phenergan is usually started within 1 hour before traveling. When used for surgery, Phenergan is usually taken the night before the surgery.
Promethazine (Oral Route) Proper Use
Children younger than 2 years of age—Use and dose must be determined by your doctor . For prevention of motion sickness: Adults and teenagers—25 mg twice daily; this initial dose should be taken one-half to one hour before traveling. The dose may be repeated eight to twelve hours later if needed.
PDF Preventing motion sickness in children
travel, as excessive sedation combined with lower oxygen partial pressure can be potentially dangerous for some children.3 n All anti-motion sickness medications are also effective antiemetics. Simple ways to prevent travel sickness2,4 n Focus child's attention elsewhere, e.g. out of the window, on the horizon where practical
Phenergan Oral: Uses, Side Effects, Interactions, Pictures ...
For motion sickness, the first dose of promethazine should be taken 30 to 60 minutes before beginning travel. ... Promethazine should not be used by children younger than 2 years because it may ...
Phenergan (Promethazine Hydrochloride)
If you are using for motion sickness, take dose at least 30-60 minutes before you start traveling. Follow all rules in how to throw away the used needles and vials. Phenergan may cause drowsiness, dizziness or blurred vision. Do not drive or do any activity where it will be unsafe until you know how you will react.
Promethazine
Promethazine. Pediatric Medication. ... Use with care in children 2 years of age and older. Talk with the doctor. Before your child takes this drug, tell the doctor if your child is taking any drugs that can cause breathing problems. ... If this drug is used to prevent motion sickness, give 30 to 60 minutes before travel. Liquid: Measure liquid ...
Promethazine: drowsy (sedating) antihistamine that relieves ...
Promethazine is used for: short-term sleep problems ( insomnia) - including when a cough, cold or itching is keeping you awake at night. allergies, including hay fever and hives (urticaria) feeling and being sick (vomiting) - due to motion sickness or vertigo. cold symptoms, such as coughing and a runny nose.
Phenergan 10mg Tablets
Children over 10 years and adults (including the elderly): Start with one tablet (10mg) twice a day; This may be increased to a maximum of two tablets (20mg) three times a day; For treatment and prevention of feeling sick or being sick (such as travel sickness) Children 2-5 years: Phenergan Elixir should be given in this age group; Children 5 ...
PDF Phenergan (fen-er-gan)
Phenergan be used in children 2 years of age or older. Allergic Disorder • Adults: One to three 25mg tablets as a single dose at ... If you are taking Phenergan for travel sickness or nausea and vomiting, take your dose as soon as you remember. If you are taking Phenergan for sedation, take your dose as ...
Phenergan Elixir
For children over 10 years and adults, Phenergan Tablets may be more convenient; For treatment and prevention of feeling sick or being sick (such as travel sickness) Children 2-5 years: One 5ml spoonful the night before the journey; This may be repeated after 6-8 hours if necessary;
Phenergan
Phenergan must not be used in children under 2 years of age, due to the potential for fatal respiratory depression. ... Travel sickness. Children 6-12 years. 10 mL. Children 2-5 years. 5 mL. To be taken the night before travel and repeated after 6-8 hours on the following day if required.
PHENERGAN 10 MG TABLETS
Children over 10 years and adults (including the elderly): Start with one tablet (10mg) twice a day; This may be increased to a maximum of two tablets (20mg) three times a day; For treatment and prevention of feeling sick or being sick (such as travel sickness) Children 2-5 years: Phenergan Elixir should be given in this age group
Preventing motion sickness in children
Susceptibility peaks around 10-12 years of age. Motion sickness in children occurs mainly during car, train and air travel, but also may occur on amusement park rides and during virtual reality immersion. 1. There are simple preventative measures which may reduce the likelihood of travel sickness . If these fail, pharmacological therapies may ...
PDF Australian Product Information Phenergan (Promethazine Hydrochloride
Children: 2 - 5 years: 5 to 15 mL as a single dose at night Travel sickness Children: 6 -12 years: 10 mL Children: 2 - 5 years: 5 mL To be taken the night before travel and repeated after 6-8 hours on the following day if required. Nausea and vomiting Children: 6 - 12 years: 10 mL every 4 to 6 hours to a maximum daily dose of 25 mL
Promethazine For Children Under 2 Years Old
Dosing in children over two years old is weight-based, and depends on what it is being used for. For the prevention of motion sickness: [3] 0.25 to 0.5 mg/kg/dose given 30 minutes to 2 hours before travel and every six to twelve hours as needed. The maximum amount per dose is 25 mg. Most sources recommend using the lowest dose possible and ...
| Expert advice
Doctors issue warning: phenergan kids side-effects are real. A long haul flight with a toddler is rarely easy. Once they start walking, toddlers have an insatiable curiosity that can not be confined to a small seat for 20 hours. The in-flight entertainment system is no help for a toddler with a desire to walk and walk constantly.
Phenergan for travel sickness in children?
My sister gets incredibly sick and phenergan worked for her. In my opinion its nothing to do with 'entertaining' your child, if the child was ill at home, you would give them medicine, why should travelling be any different. A while ago, my doctor suggested Phenergan to help me sleep at nights.

Phenergan (Promethazine) against motion sickness and nausea

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Motion sickness

In this article :

Is motion sickness normal?

Triggers for motion sickness

Prepare for your journey

Plan where you sit

Breathe fresh air

Use your eyes and ears differently

Treat your tummy gently

Try alternative treatments

Side-effects of motion sickness medicines

Antihistamines

Hyoscine patch

Prochlorperazine

Metoclopramide

Domperidone

Ondansetron

Further reading and references

Article History

Next review due: 14 Mar 2028

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