phenergan travel sickness liquid

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Phenergan (Promethazine) against motion sickness and nausea

The unpleasant symptoms of travel sickness (aeroplane, ship, car or bus) can be prevented by a drug called Phenergan. Its active ingredient is called Promethazine. It is an antihistamine that helps to prevent the effects of histamine in the body, helping you to avoid many unpleasant symptoms associated with travelling. It must be taken as a preventative measure to get the best possible effect to make the trip to the destination as easy going as possible.

What’s on this page?

How does phenergan work.

The active ingredient in this medicine is Promethazine. The focus of the treatment is the class of sedative antihistamines (calming antihistamine), after taking the pill it therefore prevents histamine from affecting. It can reduce the irritating symptoms associated with movement disorders such as nausea and dizziness. In order to fully understand how this drug works, we must first look at what the antihistamines are and how they work in the body.

How do antihistamines work in motion?

Histamines are natural substances in the body, usually found from the immune system. When the body experiences imbalance it releases histamine that binds to different receptors. This can then cause disturbing symptoms. For someone who is allergic to histamines, they can cause itching around the eyes and a runny nose, while others may have symptoms of motion sickness such as, nausea, vomiting and dizziness. Imbalance occurs when the eye sees a different movement than what the inner ear feels.

Antihistamines inhibit histamines from binding to certain receptors, so there is no “space” for histamines. When histamines cannot bind to these receptors, the symptoms of motion sickness are prevented.

The effect is best when the antihistamines are taken before the symptoms develop. In this way, histamines cannot bind in certain areas. However, it may also be helpful if the drug is taken after the onset of symptoms because the antihistamines are so powerful that they can push the histamine away from the receptors.

Sedative or soothing effect

Phenergan belongs to the category of sedative antihistamines, so it is not suitable to be used if you plan to drive a car. It can only be used if you are a passenger in a car or a ship, plane, train or bus. However, it should be noted that everyone feels the effects of Phenergan differently, so some might still be close to their normal state while others might feel very sleepy.

Phenergan 25 mg: How should I use it?

This medicine is available in various forms, both in tablets and as an oral solution. The oral solution is typically used by children – however, only according to the doctor’s instructions. The tablets for adults contain 25 mg of the active substance and are taken with a glass water.

For the best effect, it is best to take the tablet before the start of the movement, i.e. about 30 to 60 minutes before the expected start. The effects of the medicine last around 5 to 14 hours in the blood stream and therefore it lasts during the whole trip for most people.

Remember that you may become very drowsy and your muscles may become tired after taking the medicine. However, the effect may differ between people and after you have used it a couple of times. After use, you can quickly understand how much the medicine affects you.

Alcohol can weaken the effects of the drug and therefore it is not recommended to drink alcohol and use the medicine simultaneously.

Are there any side effects?

All medicines can cause side effects to some extent. This is, among other things, the reason why most medicines can only be purchased with a prescription from a doctor. This also applies to Phenergan, although most do not experience any side effects. The most common side effects are a dry mouth and feeling fatigue, as mentioned earlier. Some have side effects such as dizziness, lack of urination, blurred vision and confusion. Rare side effects include anemia and allergic reactions. If you notice any serious side effects, contact your doctor immediately.

Is Phenergan suitable for me?

Most people who suffer from motion sickness while travelling either on the sea or in the air can take advantage of this medicine. However, care should be taken with regard to the simultaneous use of other medicines or other conditions you might be experiencing. This applies to situations in which you have sleep apnea, impaired hepatic or renal function or glaucoma. In addition, it may also affect with many antidepressants and sedatives.

Is there other natural options for Phenergan?

In addition to preventative medicines, there are other measures you can take to reduce discomfort during the movement:

• make sure you get enough rest before your trip
• drink a lot of water
• if possible, get fresh air – stop the car and have breaks while driving, spend time up on the deck while on a ship or try to go out from the airport
• be sure to look out from the window and avoid reading

Can I buy Phenergan online?

Phenergan is a prescription medication. You can visit your doctor and get a prescription that you can then use in a pharmacy when buying the medicine. Another possibility is to purchase the drug through an approved online clinic where your doctor will digitally assess whether the medicine is suitable for you or not. If the drug is right for you, you get a digital prescription and the medication can be sent to your home. This process saves you a lot of time, as you do not have to book a time from the doctor or go to the clinic physically.

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Promethazine (Oral Route)

Description and brand names.

Drug information provided by: Merative, Micromedex ®

US Brand Name

Descriptions.

Promethazine is used to relieve or prevent the symptoms of hay fever, allergic conjunctivitis (inflammation of the eye), and other types of allergy or allergic reactions. It works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. It can sometimes close up the bronchial tubes (air passages of the lungs) and make breathing difficult .

Promethazine is also used to prevent and control motion sickness, nausea, vomiting, and dizziness. In addition, it may be used to help people go to sleep and control their pain or anxiety before or after surgery or other procedures .

Promethazine may also be used for other conditions as determined by your doctor .

This medicine is only available with your doctor's prescription .

This product is available in the following dosage forms:

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of promethazine in the pediatric population. Safety and efficacy have not been established in children below 2 years of age. Caution should be used when this medicine is given to children 2 years of age and older .

Insufficient information is available on the relationship of age to the effects of promethazine in geriatric patients. However, elderly patients may be more sensitive to the side effects of this medicine (such as confusion and severe drowsiness) than in younger adults, and are more likely to have age-related heart or blood vessel disease, liver problems, and kidney disease, which may require adjustment of dosage in patients receiving promethazine .

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Calcium Oxybate
• Dronedarone
• Levoketoconazole
• Magnesium Oxybate
• Mesoridazine
• Piperaquine
• Potassium Citrate
• Potassium Oxybate
• Sodium Oxybate
• Sparfloxacin
• Terfenadine
• Thioridazine
• Tranylcypromine
• Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amisulpride
• Amitriptyline
• Apomorphine
• Aripiprazole
• Aripiprazole Lauroxil
• Arsenic Trioxide
• Azithromycin
• Benzhydrocodone
• Buprenorphine
• Butorphanol
• Cannabidiol
• Carbinoxamine
• Chloroquine
• Chlorpromazine
• Ciprofloxacin
• Clarithromycin
• Clofazimine
• Clomipramine
• Clothiapine
• Daridorexant
• Desipramine
• Deutetrabenazine
• Dexmedetomidine
• Dihydrocodeine
• Disopyramide
• Domperidone
• Encorafenib
• Entrectinib
• Epinephrine
• Erythromycin
• Escitalopram
• Fexinidazole
• Flibanserin
• Fluconazole
• Fostemsavir
• Gabapentin Enacarbil
• Gatifloxacin
• Gemifloxacin
• Glycopyrrolate
• Glycopyrronium Tosylate
• Gonadorelin
• Granisetron
• Halofantrine
• Haloperidol
• Hydrocodone
• Hydromorphone
• Hydroxychloroquine
• Hydroxyzine
• Iloperidone
• Inotuzumab Ozogamicin
• Ketoconazole
• Lemborexant
• LetibotulinumtoxinA-wlbg
• Levocetirizine
• Levofloxacin
• Levorphanol
• Lumefantrine
• Macimorelin
• Methacholine
• Metoclopramide
• Metrizamide
• Metronidazole
• Mifepristone
• Mirtazapine
• Mobocertinib
• Morphine Sulfate Liposome
• Moxifloxacin
• Norfloxacin
• Nortriptyline
• Oliceridine
• Ondansetron
• Osilodrostat
• Osimertinib
• Oxaliplatin
• Oxymorphone
• Paliperidone
• Panobinostat
• Pasireotide
• Pentamidine
• Pentazocine
• Periciazine
• Phenobarbital
• Pimavanserin
• Posaconazole
• Procainamide
• Procarbazine
• Prochlorperazine
• Propafenone
• Protriptyline
• Quizartinib
• Remifentanil
• Remimazolam
• Revefenacin
• Ropeginterferon Alfa-2b-njft
• Scopolamine
• Secretin Human
• Selpercatinib
• Sevoflurane
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Solifenacin
• Telithromycin
• Tetrabenazine
• Triclabendazole
• Trifluoperazine
• Trimipramine
• Triptorelin
• Vemurafenib
• Venlafaxine
• Voclosporin
• Voriconazole
• Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aminolevulinic Acid
• Belladonna Alkaloids
• Evening Primrose
• Phenylalanine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Brain disease or injury or
• Breathing or lung problems (e.g., asthma) or
• Comatose state (unconscious) or
• Reye's syndrome or
• Sleep apnea, history of—Promethazine should NOT be used in patients with any of these conditions .
• Bone marrow disease or
• Enlarged prostate or
• Glaucoma or
• Heart or blood vessel disease or
• Intestinal tract obstruction or
• Jaundice or
• Liver disease or
• Neuroleptic malignant syndrome, or history of, or
• Stomach ulcer or
• Urinary tract blockage or difficult urination—Use with caution. This medicine may make these conditions worse .
• Seizure disorders—This medicine may increase the chance of seizures especially in patients who are also using narcotic or anesthetic medicines .

This medicine can be taken with food or a glass of water or milk to lessen stomach irritation if necessary.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• Adults and teenagers—12.5 milligrams (mg) before meals and at bedtime; or 25 mg at bedtime as needed.
• Children 2 years of age and older—Your doctor will determine dose based on the weight and/or size of the child. The dose is usually 6.25 to 12.5 mg three times a day; or 25 mg at bedtime as needed.
• Children younger than 2 years of age—Use and dose must be determined by your doctor .
• Adults and teenagers—25 mg twice daily; this initial dose should be taken one-half to one hour before traveling. The dose may be repeated eight to twelve hours later if needed. On other days of travel, 25 mg may be taken on arising and again before the evening meal.
• Children 2 years of age and older—Your doctor will determine dose based on the weight and/or size of the child. The dose is usually 12.5 to 25 mg one-half to one hour before traveling. The dose may be repeated eight to twelve hours later if needed.
• Adults and teenagers—25 mg for the first dose, then 12.5 to 25 mg every four to six hours if needed.
• Children 2 years of age and older—Your doctor will determine dose based on the weight and/or size of the child. The dose is usually 0.5 mg per pound of body weight (1.1 mg per kg) or 12.5 to 25 mg every four to six hours as needed.
• Adults and teenagers—25 to 50 mg.
• Children 2 years of age and older—Your doctor will determine dose based on the weight and/or size of the child. The dose is usually 12.5 to 25 mg.
• Adults and teenagers—50 mg the night before surgery; 25 to 50 mg after surgery.
• Children 2 years of age and older—Your doctor will determine dose based on the weight and/or size of the child. The dose is usually 0.5 mg per pound of body weight (1.1 mg per kg) or 12.5 to 25 mg the night before surgery or after the surgery.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Do not keep outdated medicine or medicine no longer needed.

Keep out of the reach of children.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects .

This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor .

This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert .

This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, antidepressants, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your medical doctor or dentist before taking any of the above while you are taking this medicine.

Check with your doctor right away if you have symptoms of pale or blue lips, fingernails, or skin; difficult or troubled breathing; irregular, fast, slow, or shallow breathing; or shortness of breath. These could be signs of a condition called respiratory depression .

Check with your doctor right away and stop taking your medicine (if directed by your doctor) if you have muscle stiffness, fever, difficult or fast breathing, seizures, fast heartbeat, increased sweating, loss of bladder control, unusually pale skin, or tiredness or weakness. These may be symptoms of a serious condition called neuroleptic malignant syndrome (NMS) .

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine .

This medicine may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections .

This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds .

This medicine controls nausea and vomiting. For this reason, it may cover up some of the signs of overdose caused by other medicines or the symptoms of encephalopathy or Reye's syndrome. This will make it difficult for your doctor to diagnose these conditions. Make sure your doctor knows that you are taking this medicine .

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking this medicine and get emergency help immediately if any of the following effects occur:

• Convulsions (seizures)
• difficult or unusually fast breathing
• fast heartbeat or irregular pulse
• high or low (irregular) blood pressure
• increased sweating
• loss of bladder control
• severe muscle stiffness
• unusually pale skin
• unusual tiredness or weakness

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

• Abdominal or stomach pain
• black, tarry stools
• bleeding gums
• blood in urine or stools
• bloody nose
• blurred vision
• chest pain or discomfort
• clay-colored stools
• confusion as to time, place, or person
• cough or hoarseness
• decreased awareness or responsiveness
• difficulty or troubled breathing
• double vision
• fast, pounding, or irregular heartbeat or pulse
• fever with or without chills
• fixed position of eye
• heavier menstrual periods
• holding false beliefs that cannot be changed by fact
• hyperexcitability
• increased or decreased blood pressure
• irregular, fast or slow, or shallow breathing
• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• lightheadedness, dizziness, or fainting
• loss of appetite
• lower back or side pain
• mimicry of speech or movements
• nasal stuffiness
• noisy breathing
• not breathing
• painful or difficult urination
• pale or blue lips, fingernails, or skin
• peculiar postures or movements, mannerisms or grimacing
• pinpoint red spots on skin
• seeing double
• seeing, hearing, or feeling things that are not there
• severe sleepiness
• shortness of breath
• slow or irregular heartbeat
• sore throat
• sores, ulcers, or white spots on lips or in mouth
• sticking out of tongue
• swollen glands
• tightness in chest
• uncontrolled twisting movements of neck
• unpleasant breath odor
• unusual bleeding or bruising
• unusual excitement, nervousness, or restlessness
• vomiting of blood
• yellow eyes or skin

Symptoms of overdose

• Discouragement
• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• excessive muscle tone
• feeling of warmth
• feeling sad or empty
• irritability
• lack of appetite
• loss of interest or pleasure
• muscle tension or tightness
• overactive reflexes
• pupils of eyes large and not moving or responding to light
• redness of the face, neck, arms and occasionally, upper chest
• shakiness and unsteady walk
• sudden death
• trouble concentrating
• trouble sleeping
• unconsciousness
• unsteadiness, trembling, or other problems with muscle control or coordination
• unusual paleness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• blistering, crusting, irritation, itching, or reddening of skin
• continuing ringing or buzzing or other unexplained noise in ears
• cracked, dry, scaly skin
• false or unusual sense of well-being
• hearing loss
• hives or welts
• increased sensitivity of skin to sunlight
• lack of coordination
• loss of strength or energy
• muscle pain or weakness
• redness or other discoloration of skin
• relaxed and calm
• unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: April 01, 2024

Original article: https://www.mayoclinic.org/drugs-supplements/promethazine-oral-route/proper-use/DRG-20070609

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Promethazine Avomine, Phenergan, Sominex

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Promethazine

Avomine, phenergan, sominex, in this article, about promethazine, before taking promethazine, how to take promethazine, getting the most from your treatment, can promethazine cause problems, how to store promethazine, important information about all medicines.

Promethazine belongs to a group of medicines known as sedating antihistamines . It has several uses.

It is used to prevent (or treat) feelings of sickness (nausea). It is commonly recommended for sickness associated with travel and for vertigo .

It is also used to relieve allergies such as hay fever and allergic skin rashes .

Promethazine also makes you feel sleepy (has a sedative effect). It may be taken (for a few days only) to help promote sleep in adults with sleeping problems . It has been popular in the past as a means of 'settling' children, but promethazine should not be used in this way.

Promethazine is available on prescription, or you can buy it without a prescription at pharmacies. It is not suitable for children under 2 years of age.

To make sure this is the right treatment for you, before you start taking promethazine it is important that you discuss the treatment with a doctor or pharmacist if:

• You are pregnant, trying for a baby or breastfeeding.
• You have a problem with the way your liver works, or if you have a problem with your kidneys.
• You have a slow or irregular heartbeat.
• You have a condition which causes increased pressure in your eyes, such as glaucoma.
• You have prostate problems or if you have been experiencing any difficulty passing urine.
• You know you have a blockage in your small intestines.
• You have epilepsy.
• You have any long-term breathing problems, such as asthma or chronic obstructive pulmonary disease (COPD).
• You have a low level of potassium in your blood (hypokalaemia).
• You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
• You have ever had an allergic reaction to a medicine.
• Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. There are a number of different brands and strengths of promethazine tablet. The manufacturer's leaflet will give you more information about the brand you have been given. It will also contain a full list of the side-effects which you may experience from taking promethazine.
• Take promethazine exactly as your doctor or pharmacist has told you to. You may be asked to take one or more doses during a day, depending upon the reason why you are taking it.
• If you are taking promethazine to prevent travel sickness, it is usually recommended that you take the first dose at bedtime on the evening before you are due to travel. You can then take a further dose on the morning of your travel if needed.
• You can take promethazine before or after meals. Some people find it helps to swallow the tablets with a drink of water.
• If you are giving promethazine liquid medicine to a child, make sure you follow the dosing instructions on the bottle carefully so that you measure out the correct dose for the age of your child.
• Most people only need to take an antihistamine for a short while when they have symptoms. You should stop taking promethazine once your symptoms have eased. Do not take promethazine for more than a few days for sleeping problems.
• Promethazine may cause drowsiness and blurred vision. If this happens to you, do not drive and do not use tools or machines. Alcohol will make the drowsiness worse, so it is best not to drink alcohol while you are on promethazine.
• If you are pregnant, only take promethazine on the advice of your doctor. Do not take promethazine in the last two weeks before your baby is born as it could cause side-effects for your baby.
• If you are having an operation or any treatment (particularly if it is to test for an allergy), tell the person carrying out the treatment that you are taking promethazine.
• Promethazine may cause your skin to become more sensitive to sunlight than normal. Use a sunscreen that protects against UVA light and has a sun protection factor (SPF) of at least 15, especially in strong sunlight or until you know how your skin reacts. Do not use sunbeds.
• If you buy any medicines, check with a pharmacist that they are safe to take with an antihistamine. This is because a number of other medicines can interfere with the way promethazine works and can increase the risk of side-effects.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with promethazine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any continue or become troublesome.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

• Keep all medicines out of the reach and sight of children.
• Store in a cool, dry place, away from direct heat and light.

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Further reading and references

Manufacturer's PIL, Phenergan® 10 mg Tablets ; Sanofi, The electronic Medicines Compendium. Dated October 2021.

Manufacturer's PIL, Sominex® 20 mg Tablets ; Teva UK Ltd, The electronic Medicines Compendium. Dated May 2022.

Medicines Complete BNF 86th Edition ; British Medical Association and Royal Pharmaceutical Society of Great Britain, London.

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• Acrivastine for allergies (Benadryl Allergy Relief)
• Levocetirizine for allergy (Xyzal)
• Mizolastine tablets (Mizollen)
• Antihistamines

Hello....I am a 43 years old male with generaklly in good health.Symptoms : Upper back discomfort and pain while smelling perfume, air freshener or cooking then it can move into the chest in front.... yaz_34049

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Phenergan (promethazine): for allergies, travel sickness and sleep

Everything you need to know about taking Phenergan

How does Phenergan work?

Phenergan tablets and elixir contain the active ingredient promethazine hydrochloride, which is a type of medicine called a sedating antihistamine. It works by preventing the actions of histamine.

For allergies

Histamine is a substance produced by the body as part of its defence mechanisms. It causes the symptoms of allergic reactions. These can include inflammation in the nose or airways, rashes, and itching of the skin, eyes, nose or throat. Promethazine blocks histamine from binding to its receptors in various parts of the body and this stops it causing the symptoms of an allergic reaction.

For travel sickness

Promethazine also blocks histamine receptors in an area of the brain called the vomiting centre. This part of the brain is activated when it gets nerve messages from a part of the inner ear called the vestibular apparatus. It's responsible for making you feel sick and for the vomiting reflex. Promethazine stops the vomiting centre being activated.

Promethazine is known as a sedating antihistamine because it enters the brain in significant quantities and makes you feel sleepy. You can use it for short periods of time to help you get to sleep if you're having trouble sleeping.

Who should not take Phenergan?

Phenergan is not suitable for:

• Children under two years of age.
• People with reduced awareness, slow reactions or extreme drowsiness due to medicines or illness that reduce activity in the central nervous system (CNS depression).
• People in a comatose state.
• People who have taken a type of medicine called a monoamine oxidase inhibitor (MAOI) in the past 14 days.

Some people may need a lower Phenergan dose or extra monitoring. Get medical advice before taking Phenergan if you:

• are over 65 years old
• have kidney or liver problems
• suffer from asthma , bronchitis or a condition called bronchiectasis (this involves persistent and progressive widening of the airways due to lung infections or lung disease such as cystic fibrosis )
• have severe heart disease
• have closed angle glaucoma
• suffer from epilepsy
• have a blockage of the opening from the stomach into the intestines (pyloro-duodenal obstruction)
• have problems passing urine, for example men with an enlarged prostate gland .

Is it safe to use Phenergan if pregnant?

Promethazine should only be used during pregnancy if your doctor feels the expected benefit to the mother outweighs any potential risks to the developing baby. It should not be used during the last few weeks of pregnancy, because if taken during this time it may cause irritability or excitement in the baby after birth. If you are or think you could be pregnant don't take Phenergan without consulting your doctor first.

Read more about using promethazine during pregnancy here

Is it safe to use Phenergan if breastfeeding?

Small amounts of promethazine may pass into breast milk. Although unlikely, there is a risk that it may cause drowsiness, irritability or excitement in a nursing baby. If you are breastfeeding don't take Phenergan without getting medical advice from your doctor first.

How do you take Phenergan?

The Phenergan dose needed and how often to take it depends on what you are using the medicine for and the age of the person being treated. Always follow the instructions in the leaflet that comes with the medicine, or the instructions given by your doctor or pharmacist. Do not exceed the recommended dose.

Phenergan usual to take a dose two or three times a day for allergies. To help sleep you take a dose before going to bed and to prevent travel sickness you take a dose the night before the journey.

You can take Phenergan tablets and elixir either with or without food. Swallow the tablets whole with a drink of water.

If you or your child's symptoms don't go away or get worse despite taking Phenergan, get advice from your doctor or pharmacist. Don't take Phenergan for longer than seven days without getting medical advice from your doctor.

Possible side effects of Phenergan

Medicines and their possible side effects can affect people in different ways. The following are some of the side effects that may be associated with promethazine. Just because a side effect is stated here doesn't mean that all people taking Phenergan will experience that or any side effect. Side effects are more likely to be experienced by elderly people and children.

Common side effects (affect between 1 in 10 and 1 in 100 people)

• Feeling tired or sleepy.
• Feeling restless.
• Nightmares.
• Feeling disorientated.
• Blurred vision.
• Difficulty passing urine.
• Confusion, particularly in elderly people.
• Excitability in children.
• Increased sensitivity of the skin to sunlight (photosensitivity). If you can't avoid strong sunlight, use a sunscreen lotion or make sure your skin is protected with clothing.

Other possible side effects

• Loss of appetite.
• Awareness of your heartbeat (palpitations).
• Low blood pressure (hypotension).
• Abnormal movements of the hands, legs, face, neck or tongue, eg tremor, twitching, rigidity. See your doctor if you experience this.
• Jaundice. See your doctor if you get yellowing of your skin or whites of your eyes
• Problems with your blood cells. See your doctor if you get unusual bruising, bleeding, fever, mouth ulcers, sore throat or feel generally tired and unwell.

You should read the patient information leaflet that is supplied with your medication for more information about side effects associated with promethazine. You can find a copy of this here

If you think you have experienced side effects from this medicine you can report them using the yellow card scheme .

Can I take Phenergan with other medicines?

If you're already taking any medicines, including those bought without a prescription and herbal medicines, it's important to check with your pharmacist before you take Phenergan as well. Similarly, check with your doctor or pharmacist before taking any new medicines with Phenergan, to make sure that the combination is safe .

Don't take Phenergan with other medicines that contain promethazine; these include Sominex, Avomine, Night nurse and Fedril.

Painkillers with promethazine

It is fine to take Phenergan with paracetamol or ibuprofen. However it's best to avoid taking it with co-codamol, co-dydramol or codeine as this can make you very sleepy.

Antidepressants with promethazine

Don't take Phenergan if you have taken a type of antidepressant called a monoamine oxidase inhibitor (MAOI) in the last 14 days, for example phenelzine, tranylcypromine, isocarboxazid.

If you're taking an antidepressant that makes you sleepy, or that gives you a dry mouth, constipation or difficulty passing urine, taking Phenergan as well can make this worse.

Phenergan with other medicines that cause sleepiness

You are more likely to feel very sleepy if you take Phenergan with other medicines that make you sleepy, such as:

• amitriptyline
• antipsychotics, for example haloperidol, chlorpromazine
• barbiturates, for example phenobarbital, amobarbital
• benzodiazepines, for example diazepam, temazepam
• other sedating antihistamines, such as hydroxyzine, chlorphenamine, diphenhydramine
• sleeping tablets, such as zopiclone
• strong opioid painkillers, such as morphine, tramadol.

Other medicines with similar side effects

You are more likely to get a dry mouth, constipation, difficulty passing urine or confusion if you take Phenergan with other medicines that can cause these types of side effects, these include the following:

• antimuscarinic medicines for Parkinson's symptoms, for example procyclidine, orphenadrine, trihexiphenidyl
• antimuscarinic medicines for urinary incontinence, for example tolterodine, oxybutynin
• antipsychotics, for example chlorpromazine, clozapine
• antispasmodics, for example hyoscine, atropine
• muscle relaxants such as baclofen.

Antihistamines may also oppose the effect of betahistine (used to treat Ménière's disease).

Read more detailed information about medicines that may interact with promethazine here

Last updated 23.10.2019

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Promethazine

Why is this medication prescribed, how should this medicine be used, other uses for this medicine, what special precautions should i follow, what special dietary instructions should i follow, what should i do if i forget a dose, what side effects can this medication cause, what should i know about storage and disposal of this medication, in case of emergency/overdose, what other information should i know, brand names, brand names of combination products, important warning:.

Promethazine may cause breathing to slow or stop, and may cause death in children. Promethazine should not be given to babies or children who are younger than 2 years old and should be given with caution to children who are 2 years of age or older. Combination products containing promethazine and codeine should not be given to children younger than 16 years old. Promethazine should not routinely be used to treat vomiting in children; it should only be used in specific cases when a doctor decides that it is needed. Tell your child's doctor if your child has any condition that affects his/her breathing such as lung disease, asthma, or sleep apnea (stops breathing for short periods of time during sleep). Tell your doctor or pharmacist about all the medications your child is taking, especially barbiturates such as phenobarbital (Luminal), medications for anxiety, narcotic medications for pain, sedatives, sleeping pills, and tranquilizers. Call your child's doctor immediately and get emergency medical treatment if your child has difficulty breathing, wheezes, slows or pauses in breathing, or stops breathing.

Talk to your doctor about the risks of giving promethazine to your child.

Promethazine is used to relieve the symptoms of allergic reactions such as allergic rhinitis (runny nose and watery eyes caused by allergy to pollen, mold or dust), allergic conjunctivitis (red, watery eyes caused by allergies), allergic skin reactions, and allergic reactions to blood or plasma products. Promethazine is used with other medications to treat anaphylaxis (sudden, severe allergic reactions) and the symptoms of the common cold such as sneezing, cough, and runny nose. Promethazine is also used to relax and sedate patients before and after surgery, during labor, and at other times. Promethazine is also used to prevent and control nausea and vomiting that may occur after surgery, and with other medications to help relieve pain after surgery. Promethazine is also used to prevent and treat motion sickness. Promethazine helps control symptoms, but will not treat the cause of the symptoms or speed recovery. Promethazine is in a class of medications called phenothiazines. It works by blocking the action of a certain natural substance in the body.

Promethazine comes as a tablet and syrup (liquid) to take by mouth and as a suppository to use rectally.When promethazine is used to treat allergies, it is usually taken one to four times daily, before meals and/or at bedtime. When promethazine is used to relieve cold symptoms, it is usually taken every 4 to 6 hours as needed. When promethazine is used to treat motion sickness, it is taken 30 to 60 minutes before travel and again after 8 to 12 hours if needed. On longer trips, promethazine is usually taken in the morning and before the evening meal on each day of travel. When promethazine is used to treat or prevent nausea and vomiting it is usually taken every 4 to 6 hours as needed. Promethazine may also be taken at bedtime the night before surgery to relieve anxiety and produce quiet sleep. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take promethazine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Promethazine suppositories are for rectal use only. Do not try to swallow the suppositories or insert in any other part of your body.

If you are taking promethazine liquid, do not use a household spoon to measure your dose. Use the measuring spoon or cup that came with the medication or use a spoon made especially for measuring medication.

To insert a promethazine suppository, follow these steps:

• If the suppository feels soft, hold it under cold, running water for 1 minute. Remove the wrapper.
• Dip the tip of the suppository in water.
• Lie down on your left side and raise your right knee to your chest. (A left-handed person should lie on the right side and raise the left knee.)
• Using your finger, insert the suppository into the rectum, about 1/2 to 1 inch (1.25 to 2.5 centimeters) in children who are 2 years of age older and 1 inch (2.5 centimeters) in adults. Hold it in place for a few moments.
• Stand up after about 15 minutes. Wash your hands thoroughly and resume your normal activities.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking promethazine,

• tell your doctor and pharmacist if you are allergic to promethazine, other phenothiazines (certain medications used to treat mental illness, nausea, vomiting, severe hiccups, and other conditions) or any other medications. Also tell your doctor and pharmacist if you have ever had an unusual or unexpected reaction when you took promethazine, another phenothiazine, or any other medication. Ask your doctor or pharmacist if you do not know if a medication you are allergic to is a phenothiazine.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants ('mood elevators') such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); antihistamines; azathioprine (Imuran);barbiturates such as phenobarbital (Luminal); cancer chemotherapy; epinephrine (Epipen); ipratropium (Atrovent)medications for anxiety, irritable bowel disease, mental illness, motion sickness, Parkinson's disease, seizures, ulcers, or urinary problems; monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and selegiline (Eldepryl, Emsam, Zelapar); narcotics and other pain medication; sedatives; sleeping pills;and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you have or have ever had an enlarged prostate (a male reproductive gland); glaucoma (a condition in which increased pressure in the eye can lead to gradual loss of vision); seizures; ulcers; blockage in the passage between the stomach and intestine; blockage in the bladder; asthma or other lung disease; sleep apnea; cancer;any condition that affects the production of blood cells in your bone marrow; or heart or liver disease. If you will be giving promethazine to a child, also tell the child's doctor if the child has any of the following symptoms before he or she receives the medication: vomiting, listlessness, drowsiness, confusion, aggression, seizures, yellowing of the skin or eyes, weakness, or flu-like symptoms. Also tell the child's doctor if the child has not been drinking normally, has had excessive vomiting or diarrhea, or appears dehydrated.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking promethazine, call your doctor.
• talk to your doctor about the risks and benefits of taking promethazine if you are 65 years of age or older. Older adults should not usually take promethazine because it is not as safe as other medications that can be used to treat the same conditions.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking promethazine.
• you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you. If you are giving promethazine to a child, watch the child to be sure he or she does not get hurt while riding a bike or participating in other activities that could be dangerous.
• ask your doctor about the safe use of alcohol while you are taking this medication. Alcohol can make the side effects of promethazine worse.
• plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Promethazine may make your skin sensitive to sunlight.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Promethazine can cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• listlessness
• difficulty falling asleep or staying asleep
• ringing in ears
• blurred or double vision
• loss of coordination
• nervousness
• restlessness
• hyperactivity
• abnormally happy mood
• stuffy nose

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

• slowed breathing
• breathing stops for a short time
• stiff muscles
• decreased alertness
• fast or irregular pulse or heartbeat
• abnormal or uncontrollable movements
• hallucinations (seeing things or hearing voices that do not exist)
• overwhelming or unmanageable fear or emotion
• uncontrollable shaking of a part of the body
• unusual bruising or bleeding
• sore throat, fever, chills, and other signs of infection
• uncontrolled eye movements
• tongue sticking out
• abnormal neck position
• inability to respond to people around you
• yellowing of the skin or eyes
• swelling of the face, eyes, lips, tongue, throat, arms, hands, feet, ankles, or lower legs
• difficulty breathing or swallowing

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( http://www.fda.gov/Safety/MedWatch ) or by phone (1-800-332-1088).

Promethazine may cause other side effects. Call your doctor if you experience any unusual problems while you are taking this medication.

Keep this medication in the carton or container it came in, tightly closed, and out of reach of children. Store promethazine tablets and liquid at room temperature and away from excess heat and moisture (not in the bathroom). Store promethazine suppositories in the refrigerator. Protect the medication from light.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( http://goo.gl/c4Rm4p ) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help . If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• difficulty breathing
• slowed or stopped breathing
• lightheadedness
• loss of consciousness
• fast heartbeat
• tight muscles that are difficult to move
• continuous twisting movements of the hands and feet
• wide pupils (black circles in the middle of the eyes)
• constipation
• abnormal excitement or agitation

Keep all appointments with your doctor.

Promethazine can interfere with the results of home pregnancy tests. Talk to your doctor if you think you might be pregnant while you are taking promethazine. Do not try to test for pregnancy at home.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking promethazine.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

• Phenergan ® ¶
• Promethegan ® Suppository
• Prometh ® VC Syrup (containing Phenylephrine, Promethazine)

¶ This branded product is no longer on the market. Generic alternatives may be available.

Promethazine (Phenergan) - Other brand names: Avomine, Sominex

On this page.

• About promethazine
• Who can and cannot take promethazine
• How and when to take promethazine
• Side effects
• How to cope with side effects of promethazine
• Pregnancy and breastfeeding
• Cautions with other medicines
• Common questions about promethazine

1. About promethazine

Promethazine is an antihistamine medicine that relieves the symptoms of allergies.

It's known as a drowsy (sedating) antihistamine, so it's more likely to make you feel sleepy than other antihistamines.

Promethazine is used for:

• short-term sleep problems ( insomnia ) – including when a cough, cold or itching is keeping you awake at night
• allergies, including hay fever and hives (urticaria)
• feeling and being sick (vomiting) – due to motion sickness or vertigo
• cold symptoms, such as coughing and a runny nose

You can buy promethazine from pharmacies, where it's often sold as Avomine, Phenergan or Sominex. Promethazine is also available on prescription.

It comes as tablets, capsules and a liquid that you swallow.

You can also buy promethazine mixed with other medicines, such as paracetamol , dextromethorphan or pseudoephedrine, to treat coughs and colds or pain.

2. Key facts

• Do not drink alcohol while taking promethazine. Alcohol increases the risks of side effects.
• To help you sleep, take promethazine 20 minutes before you go to bed. It normally takes about 30 minutes to work.
• To prevent motion sickness, take promethazine the night before a long journey or 1 to 2 hours before a short journey.
• Common side effects of promethazine include drowsiness, headaches, nightmares and feeling dizzy, restless or confused.
• When promethazine is mixed with other medicines, it's also known by the brand names Fedril and Night Nurse.

3. Who can and cannot take promethazine

Promethazine can be taken by most adults.

Children under 6 should not be given cough and cold medicines containing promethazine if they have been bought at a pharmacy. These medicines should only be given if prescribed by a doctor.

Some types of promethazine medicines are not suitable for children over 6. Some are labelled 12+ and some are labelled 16+. Your doctor or pharmacist will advise which are the safest for children.

Promethazine is not suitable for some adults. To make sure it's safe for you, tell your doctor or pharmacist if you:

• have ever had an allergic reaction to promethazine or any other medicine
• have an eye problem called primary angle closure glaucoma
• have problems peeing or emptying your bladder
• have epilepsy or any other health problem that causes seizures or fits
• are due to have an allergy test. Promethazine can affect your results, so you may need to stop taking it a few days before your test. Ask the clinic where you are due to have your allergy test
• are unable to have any alcohol – some liquid promethazine products contain a very small amount of alcohol, so check the ingredients and the packaging carefully
• are trying to get pregnant. Promethazine can affect home pregnancy tests. If you think you're pregnant, speak to your doctor so they can arrange a blood test instead

4. How and when to take promethazine

If you or your child have been prescribed promethazine, follow your doctor's instructions about how and when to take it.

Only take promethazine when you need it – for example, if you're unable to sleep because you're worrying about something or your cold symptoms are keeping you awake.

If you have bought promethazine or any medicine containing promethazine from a pharmacy, follow the instructions that come with it, or ask a pharmacist for advice.

Dosage and strength

Promethazine comes in 10mg, 20mg and 25mg tablets. Your dose depends on why you're taking it:

• short-term insomnia – you'll usually take 20mg to 50mg at night
• hay fever – you'll usually take from 10mg twice a day to 20mg, 3 times a day
• hives – you'll usually take from 10mg twice a day to 20mg 3 times a day
• preventing motion sickness – you'll usually take 25mg 1 to 2 hours before a short journey or 25mg the night before a long journey
• treating motion sickness – take 25mg as soon as possible and 25mg the same evening, followed by 25mg the following evening (if you need it)
• vertigo – the dose can vary from 25mg a day to 25mg 4 times a day

If you're taking liquid which contains 5mg of promethazine in 5ml, follow the instructions that come with the medicine for how much to take.

Doses are lower for children. Your doctor will use your child's age to work out the right dose.

Promethazine mixed with other medicines

Promethazine can come mixed with other medicines, such as paracetamol. This is usually used to treat cough and cold symptoms. Your dose will depend on the type of medicine you're taking.

Check the instructions on the packaging carefully, or ask your pharmacist or doctor if you're unsure.

How to take it

You can take promethazine tablets, capsules and liquid with or without food.

How to take tablets and capsules

Always take your promethazine tablets or capsules with a drink of water. Swallow them whole. Do not chew them.

How to take liquid

Liquid medicines containing promethazine come with a plastic syringe or spoon to help you measure out the right dose.

If you do not have a syringe or spoon, ask your pharmacist for one. Do not use a kitchen teaspoon as you will not get the right amount.

What if I forget to take it?

For motion sickness, take it as soon as you remember.

For anything else, skip the missed dose and take your next dose at the usual time.

Never take 2 doses at the same time. Never take an extra dose to make up for a forgotten one.

If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

What if I take too much?

Too much promethazine can be dangerous.

If you take more than your usual dose, you may:

• feel very sleepy
• have a very fast, irregular or pounding heartbeat (palpitations)
• have breathing problems

In serious cases, you can become unconscious or have seizures or fits and may need emergency treatment in hospital.

If your child takes too much promethazine, they may also:

• move unsteadily or stumble
• have uncontrolled movements, especially in their hands or feet
• see or hear things that are not there (hallucinations)
• have an irregular heartbeat

Urgent advice: Contact 111 for advice if:

• you take more than your usual dose of promethazine

Go to 111.nhs.uk or call 111

If you need to go to A&E do not drive yourself. Get someone else to drive you or call for an ambulance.

Take the promethazine packet or leaflet inside it, plus any remaining medicine, with you.

5. Side effects

Common side effects.

Like all medicines, promethazine can cause side effects, although not everyone gets them.

Talk to your pharmacist or doctor if these side effects bother you or do not go away:

• feeling tired during the daytime
• feeling dizzy or unsteady on your feet, or having difficulty concentrating

Promethazine can sometimes make your skin more sensitive to sunlight. Keep out of direct or strong sunlight and follow sun safety advice.

If you're over 65, you're more likely to get side effects such as:

• feeling confused
• blurred vision
• difficulty peeing

Talk to a doctor or call 111 straight away if you have these side effects.

Children are more likely to get side effects such as feeling restless or excited.

Serious side effects

Call your doctor straight away if:

• the whites of your eyes or your skin turn yellow, although this may be less obvious on black or brown skin – these can be signs of liver problems
• you notice more bruising or bleeding than normal
• you have muscle stiffness or shaking, or unusual face or tongue movements

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction ( anaphylaxis ) to promethazine.

Immediate action required: Call 999 now if:

• your lips, mouth, throat or tongue suddenly become swollen
• you're breathing very fast or struggling to breathe (you may become very wheezy or feel like you're choking or gasping for air)
• your throat feels tight or you're struggling to swallow
• your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
• you suddenly become very confused, drowsy or dizzy
• someone faints and cannot be woken up
• a child is limp, floppy or not responding like they normally do (their head may fall to the side, backwards or forwards, or they may find it difficult to lift their head or focus on your face)

You or the person who's unwell may also have a rash that's swollen, raised, itchy, blistered or peeling.

These can be signs of a serious allergic reaction and may need immediate treatment in hospital.

These are not all the side effects of promethazine. For a full list, see the leaflet inside your medicine packet.

You can report any suspected side effect using the Yellow Card safety scheme.

Visit Yellow Card for further information .

6. How to cope with side effects of promethazine

What to do about:

• feeling sleepy during the daytime – this usually wears off 12 hours after a dose. Do not drive, cycle or use tools or machinery if you're feeling this way.
• nightmares – speak to your pharmacist or doctor if these do not go away or are troubling you.
• feeling dizzy or unsteady on your feet, or having difficulty concentrating – stop what you're doing and sit or lie down until you feel better. If the feeling does not go away or is troubling you, do not take any more medicine and speak to a pharmacist or doctor.
• headaches – make sure you rest and drink plenty of fluids. Talk to your doctor if the headaches last longer than a week or are severe.

7. Pregnancy and breastfeeding

Promethazine and pregnancy.

Promethazine can be used in pregnancy. There is no good evidence that it is harmful to your baby, but it can have side effects such as drowsiness.

For the treatment of hay fever your doctor or pharmacist may recommend a non-drowsy antihistamine ( loratadine ).

Promethazine and breastfeeding

If your doctor or health visitor says your baby is healthy, promethazine can be used during breastfeeding. If you are prescribed promethazine, it's better to take occasional doses or only for a short time.

It's not known how much promethazine passes into breast milk but it is likely to be a small amount. It has been used for many years without causing babies to have side effects. However, promethazine is a drowsy antihistamine, so may also make your baby sleepy too. It may also reduce the amount of milk you produce.

If you're breastfeeding or planning to breastfeed, talk to your doctor or pharmacist, as other medicines might be better while you're breastfeeding.

If your baby is not feeding as well as usual, seems unusually sleepy, or seems irritable, or if you have any other concerns about your baby, talk to your doctor, pharmacist, health visitor or midwife.

Non-urgent advice: Tell your doctor if you're:

• trying to get pregnant
• breastfeeding

Find out more about how promethazine can affect you and your baby during pregnancy on the Best Use of Medicines in Pregnancy (BUMPs) website.

8. Cautions with other medicines

Some medicines and promethazine can affect each other and increase the chance of having side effects.

Tell your pharmacist or doctor if you're taking:

• a type of antidepressant called a monoamine oxidase inhibitor, such as phenelzine
• a type of painkiller called an opioid, such as codeine , morphine or oxycodone
• any medicine that makes you drowsy, gives you a dry mouth, or makes it difficult for you to pee – taking promethazine might make these side effects worse

If you're taking a cough or cold remedy or a painkiller containing promethazine, check carefully what the other ingredients are.

For example, promethazine often comes mixed with paracetamol . If you take 2 medicines that both contain paracetamol, there's a risk of overdose.

Ask your pharmacist for advice before you take this medicine together with any other painkillers or medicines.

Mixing promethazine with herbal remedies and supplements

There might be a problem taking some herbal remedies and supplements alongside promethazine, especially ones that cause side effects such as sleepiness, a dry mouth or making it difficult to pee.

Ask your pharmacist for advice.

Important: Medicine safety

Tell your doctor or pharmacist if you're taking any other medicines, including herbal medicines, vitamins or supplements.

9. Common questions about promethazine

Promethazine is a medicine called an antihistamine . It's classed as a drowsy (sedating) antihistamine.

When you come into contact with something you're allergic to, such as pollen or animal hair, your body produces a chemical called histamine. This can cause symptoms such as a runny nose or skin rashes.

Promethazine blocks the effects of histamine in your brain and this reduces symptoms.

It enters the brain in large quantities and this can make you feel drowsy.

Promethazine also blocks the effects of a chemical called dopamine, and this stops you feeling sick.

Promethazine blocks the effects of a natural chemical called acetylcholine.

This can help dry up a cough or runny nose, but can also cause side effects such as a dry mouth and dry nose.

Some cough and cold remedies claim to suppress your cough or stop you bringing up phlegm.

Although some people find them helpful, they're not usually recommended.

This is because there's little evidence that they're any more effective than simple home remedies and they're not suitable for everyone.

Promethazine will start to make you feel sleepy around 20 minutes after you take it and may work for up to 12 hours.

If you're taking it for a cough or cold, allergies or feeling sick (nausea), your symptoms should start to improve within 20 minutes. The medicine should work for around 4 to 6 hours.

Only take promethazine for a short time, unless your doctor says it's OK for you to take it for longer.

Speak to your pharmacist or doctor before taking promethazine for longer than the medicine leaflet recommends.

Ask them for advice if you're unsure how long you should take it for.

It's unlikely that you'll get addicted to promethazine. But it's best that you only take it for a very short time, unless your doctor tells you to take it for longer.

If you have bought a medicine containing promethazine, do not take it for longer than recommended on the packet without speaking to your pharmacist or doctor first.

If you have taken promethazine for a long time and suddenly stop taking it, it's possible you might feel dizzy, sweaty or sick, have a racing heart and have trouble sleeping.

Coming off promethazine slowly can help prevent this.

Speak to your doctor if you have taken promethazine for a long time and want to stop taking it.

Promethazine is known as a drowsy (sedating) antihistamine as it makes you sleepy.

Non-drowsy antihistamines are less likely to have this effect. These include cetirizine , fexofenadine and loratadine .

Most people prefer to take a non-drowsy antihistamine as it's less likely to interfere with their everyday routine.

You might choose to take a drowsy antihistamine, however, if you're having problems falling asleep, or if symptoms like itching or coughing are keeping you awake.

There is not enough information available to say whether one antihistamine is better than another for treating allergies.

You may need to try a few different medicines to find what works best for you. Ask your pharmacist or doctor for advice if you're unsure.

You can take 2 different antihistamines at a time, if your doctor says it's OK. If you have a severe itchy skin rash, your doctor may recommend 2 different antihistamines together for a few days.

You could take a non-drowsy antihistamine (such as cetirizine , fexofenadine or loratadine ) during the day, and a drowsy antihistamine at night if itching is making it difficult to sleep.

Do not take another drowsy antihistamine together with promethazine. It'll make you very tired and sleepy.

Other drowsy antihistamines include chlorphenamine (Piriton) and diphenhydramine (Nytol Original).

Do not take 2 antihistamines together unless you have been advised to by your doctor.

Yes. If you take it for insomnia or take it at bedtime, promethazine will help you sleep.

If you take it during the day for other conditions, such as allergies, it might make you feel sleepy during the day as well.

Yes, you can take promethazine together with some painkillers, such as paracetamol or ibuprofen .

If you take promethazine with painkillers that contain codeine (such as co-codamol or other prescription painkillers), you may feel very tired and sleepy.

It's important to check the packaging or label of your medicine carefully. This is because some promethazine products already contain a painkiller.

Do not take extra painkillers if this is the case, as there's a risk of overdose.

Speak to your pharmacist if you're not sure whether a medicine already contains a painkiller.

Do not drive a car or ride a bike if promethazine makes you sleepy during the daytime, gives you blurred vision or makes you feel dizzy, clumsy or unable to concentrate or make decisions.

This may be more likely when you first start taking promethazine, but could happen at any time (for example, when starting another medicine).

It's an offence to drive a car if your ability to drive safely is affected. It's your responsibility to decide if it's safe to drive. If you're in any doubt, do not drive.

Talk to your doctor or pharmacist if you're unsure whether it's safe for you to drive while taking promethazine. GOV.UK has more information on the law on drugs and driving .

There's no evidence to suggest that taking promethazine reduces fertility in either men or women.

But speak to a pharmacist or doctor before taking it if you're trying to get pregnant.

Promethazine does not affect any type of contraception, including the combined pill and emergency contraception .

Do not drink alcohol while you're taking promethazine.

Alcohol and promethazine together can make you sleep very deeply.

You will not be able to breathe properly and may have difficulty waking up.

You can eat normally while taking promethazine.

However, do not drink alcohol. And if you take promethazine to help you sleep, try not to have drinks that contain caffeine, like coffee, tea, cola or energy drinks. Caffeine has the opposite effect to promethazine and can stop the medicine working.

Yes, it's dangerous to take promethazine with recreational drugs. This is because it can slow or stop your heart and lungs.

Mixing promethazine and codeine in large amounts slows down the central nervous system (brain and spinal cord), which can slow breathing and heart rate.

It's even more dangerous when taken with alcohol or other drugs and has caused people to die.

Find out more about the side effects of some recreational drugs on the Frank website .

Promethazine will only help you sleep while you're taking it, so there are a number of things you can do instead to help yourself have a good night's sleep :

• set regular times for going to bed and waking up
• relax before bedtime – try taking a warm bath or listening to calming music
• use thick curtains or blinds, an eye mask and earplugs to stop you being woken up by light and noise
• avoid caffeine, cigarettes or vapes, alcohol, heavy meals and exercise for a few hours before bedtime
• do not watch TV or use phones, tablets or computers before going to bed
• do not nap during the day
• make a list of your worries and any ideas for how to solve them before you go to bed – this can help you forget about them until the morning

If you have hay fever , it helps if you do not spend too much time outside if the pollen count is high.

Tips for when you're outside

• Do not cut grass or walk on grass.
• Wear wraparound sunglasses to stop pollen getting into your eyes.
• Put Vaseline around your nostrils to help trap pollen.
• Shower and change your clothes after you have been outside to wash off pollen.

Tips for when you're inside

• Keep windows and doors shut as much as possible.
• Vacuum regularly and dust with a damp cloth.
• Do not keep fresh flowers in the house.
• Do not smoke or be around smoke as it makes hay fever symptoms worse.

The best way to prevent any sort of allergic reaction is to avoid the substance that you're allergic to, if you can.

There are some practical steps you can follow to help prevent allergies .

Related conditions

• Contact dermatitis
• Motion sickness

Useful resources

• HealthUnlocked: promethazine forum
• Allergy UK: charity
• Healthtalk: videos of real stories about sleep problems
• Itchy Sneezy Wheezy: website for parents

Page last reviewed: 27 October 2021 Next review due: 27 October 2024

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Promethazine hydrochloride

Interactions.

View interactions for promethazine

Medicinal forms and pricing

There can be variation in the licensing of different medicines containing the same drug.

Forms available from special-order manufacturers include: oral suspension, oral solution.

View all medicinal forms and pricing information

Or jump straight to:

• Oral tablet
• Oral solution
• Solution for injection

Indications and dose

For promethazine hydrochloride, symptomatic relief of allergy such as hay fever and urticaria, insomnia associated with urticaria and pruritus for promethazine hydrochloride, sedation (short-term use) for promethazine hydrochloride, sedation in intensive care for promethazine hydrochloride, by mouth, or by slow intravenous injection, or by deep intramuscular injection, nausea, vomiting, vertigo, labyrinthine disorders, motion sickness for promethazine hydrochloride, unlicensed use, unlicensed use for promethazine hydrochloride.

Not licensed for use for sedation in children under 2 years.

Important safety information

Important safety information for promethazine hydrochloride, mhra/chm advice: over-the-counter cough and cold medicines for children (april 2009).

Children under 6 years should not be given over-the-counter cough and cold medicines containing promethazine.

Contra-indications

Contra-indications for promethazine hydrochloride.

Neonate (due to significant antimuscarinic activity) (in neonates); should not be given to children under 2 years, except on specialist advice, due to the potential for fatal respiratory depression

Cautions For promethazine hydrochloride

General cautions:.

Epilepsy; pyloroduodenal obstruction; severe coronary artery disease; susceptibility to angle-closure glaucoma; susceptibility to QT interval prolongation; urinary retention

Specific cautions:

With intravenous use.

Avoid extravasation with intravenous injection

Side-effects

Side-effects for promethazine hydrochloride, general side-effects:, frequency not known.

Arrhythmias; blood disorder; confusion; dizziness; drowsiness; dry mouth; headache; hypotension; jaundice; movement disorders; palpitations; photosensitivity reaction; QT interval prolongation; urinary retention; vision blurred

Specific side-effects:

With oral use.

Agranulocytosis; angle closure glaucoma; anticholinergic syndrome; anxiety; insomnia; leucopenia; nasal congestion; nausea; rash; seizure; thrombocytopenia; tinnitus; tremor; vomiting

With parenteral use

Appetite decreased; epigastric discomfort; fatigue; haemolytic anaemia; hypersensitivity; muscle spasms; nightmare; restlessness; skin reactions

Pregnancy For promethazine hydrochloride

Most manufacturers of antihistamines advise avoiding their use during pregnancy; however, there is no evidence of teratogenicity.

Use in the latter part of the third trimester may cause adverse effects in neonates such as irritability, paradoxical excitability, and tremor.

Breast feeding

Breast feeding for promethazine hydrochloride.

Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding.

Hepatic impairment

Hepatic impairment for promethazine hydrochloride.

Manufacturer advises caution.

Renal impairment

Renal impairment for promethazine hydrochloride.

Use with caution. M

Patient and carer advice

Patient and carer advice for promethazine hydrochloride, driving and skilled tasks.

Drowsiness may affect the performance of skilled tasks (e.g. cycling or driving); sedating effects enhanced by alcohol.

Profession specific information

Profession specific information for promethazine hydrochloride, dental practitioners' formulary.

Promethazine Hydrochloride Tablets 10 mg or 25 mg may be prescribed.

Promethazine Hydrochloride Oral Solution (elixir) 5 mg/5 mL may be prescribed.

Less suitable for prescribing

Less suitable for prescribing for promethazine hydrochloride.

Promethazine is less suitable for prescribing for sedation.

Exceptions to legal category

Exceptions to legal category for promethazine hydrochloride.

Prescription only medicine restriction does not apply to promethazine hydrochloride injection where administration is for saving life in emergency.

Medicinal forms

Related treatment summaries.

• Hypnotics and anxiolytics
• Nausea and labyrinth disorders

Other drugs in class

Other drugs in class sedating antihistamines.

• Alimemazine tartrate
• Chlorphenamine maleate
• Cinnarizine
• Hydroxyzine hydrochloride
• Paracetamol with buclizine hydrochloride and codeine phosphate
• Promethazine teoclate

• Patient info
• » Patient leaflets
• » PHENERGAN 10 MG TABLETS - patient leaflet, side effects, dosage

PHENERGAN 10 MG TABLETS - patient leaflet, side effects, dosage

• R06AD02 promethazine

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Table of contents

Sources: Original (products.mhra.gov.uk)

Patient leaflet - PHENERGAN 10 MG TABLETS

Phenergan 10 mg

promethazine hydrochloride

Is this leaflet hard to see or read? Phone 0800 035 2525 f­or help

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

Always take this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you.

• Keep this leaflet. You may need to read it again
• Ask your pharmacist if you need more information or advice
• If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4 .
• You must talk to a doctor if you do not feel better or if you feel worse after 7 days.

1. What Phenergan Tablets are and what they are used for

2. What you need to know before you take Phenergan Tablets

3. How to take Phenergan Tablets

4. Possible side effects

5. How to store Phenergan Tablets

6. Contents of the pack and other information

What Phenergan Tablets are used for

Phenergan Tablets are used to treat the following conditions:

• For short term use: to treat adults with difficulty sleeping (insomnia)
• To treat allergic conditions such as hay fever or rashes (like nettle rash or hives)
• To treat or stop you feeling sick (nausea) or being sick (vomiting) such as travel sickness
• For short term use: as a sedative for

children aged 5 years and above

2. what you need to know before you take phenergan tablets

Qis do not take this medicine if:.

X The person taking the medicine is under

5 years of age

X You are allergic (hypersensitive) to promethazine hydrochloride or any of the other ingredients of Phenergan Tablets (listed in Section 6 below)

X The signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue.

X You are taking a medicine for depression called a monoamine oxidase inhibitor (MAOI). Also do not take Phenergan Tablets if you have stopped taking one of these MAOI medicines within the last 14 days. If you are not sure ask your doctor or pharmacist (see “Taking other medicines” section below)

X The person is unconscious (in a coma) or suffers from severe dizziness, drowsiness or headache

Do not take this medicine if any of the above applies to you. If you are not sure, talk to your doctor or pharmacist before taking Phenergan Tablets.

1. What Phenergan Tablets are and what they are used for

Warnings and precautions

Phenergan Tablets contain a medicine called promethazine hydrochloride. This belongs to a group of medicines called phenothiazines. It works by blocking a natural substance (histamine) that your body makes during an allergic reaction. It also works directly on the brain to help you feel more relaxed.

Check with your doctor or pharmacist

Before taking your medicine if.

You have difficulty breathing, wheezing,

tightness in the chest (asthma) or an

infection in your lungs (bronchitis)

You have epilepsy You have any serious heart problems

11503107–08

A  You have liver or kidney problems

A  You have a stomach blockage or difficulty passing water (urine)

A  You have hearing problems

A  You have increased pressure in the eye (narrow angle glaucoma)

A  You have had something called Reye’s Syndrome or possible Reye’s Syndrome signs include being sick and confused following a viral illness

If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Phenergan Tablets.

SS.hermed^andPhe­nerganTab.

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines you can buy without prescription, including herbal medicines. This is because Phenergan Tablets can affect the way some medicines work. Also some medicines can affect the way Phenergan Tablets work.

Do not take this medicine, and tell your doctor, if you are taking or have taken the following in the last 2 weeks:

• Some medicines for depression called monoamine oxidase inhibitors (MAOIs). If you are not sure ask your doctor or pharmacist

Tell your doctor or pharmacist if you are taking any of the following:

• Anticholinergic medicines – includes some medicines used for irritable bowel syndrome, asthma or weak bladder. These can increase the risk of dizziness, dry mouth and blurred eyesight
• Medicines for depression (such as amitriptyline)
• Medicines to help you to sleep or feel more relaxed (such as diazepam or zolpidem)
• Medicines such as aspirin (for arthritis and pain in your joints). Phenergan Tablets may hide the side effects of these medicines

Phenergan Tablets with food and drink Do not drink alcohol while you are taking Phenergan Tablets. This is because it can affect the way the medicine works.

Pregnancy and breast-feeding

Talk to your doctor or pharmacist before taking this medicine if you are pregnant, might become pregnant, or think you may be pregnant. Phenergan Tablets should not be taken 2 weeks before birth.

You should not take Phenergan Tablets if you are breast-feeding. This is because small amounts may pass into mothers’ milk. This can be harmful to your baby.

If you are breast-feeding or planning to breast-feed, talk to your doctor or pharmacist before taking any medicine.

I Driving and using machines

You may feel drowsy or sleepy after taking this medicine or in the morning after taking this medicine. If this happens, do not drive or use any tools or machines.

Phenergan Tablets contains lactose:

• If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

3.How to take Phenergan Tablets

Always use this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

The amount you need to take depends on the reason you are taking Phenergan Tablets. The following information will help you to decide how much you need to take.

Taking this medicine

• Take this medicine by mouth
• Do not take for longer than 7 days. If your symptoms worsen or do not improve after 7 days talk to your doctor or pharmacist
• If you feel the effect of your medicine is too weak or too strong, do not change the dose yourself, but ask your doctor

How much to take

The recommended dose is:

For allergies (such as hay fever, rashes and hives)

Children 2–5 years:

• Phenergan Elixir should be given in this age group

Children 5–10 years:

• A single dose of either one or two tablets (10mg or 20mg) given at night or one tablet (10mg) given twice a day
• DO NOT give more than two tablets (20mg) each day

Children over 10 years and adults (including the elderly):

• Start with one tablet (10mg) twice a day
• This may be increased to a maximum of two tablets (20mg) three times a day

For treatment and prevention of feeling sick or being sick (such as travel sickness)

• A single tablet to be taken the night before the journey
• This may be repeated after 6–8 hours if necessary
• Two tablets (20mg) to be taken the night before the journey

As a short term paediatric sedative and for short term treatment of insomnia in adults

• Two tablets (20mg) given as a single dose at night time

Children over 10 years and adults

(including the elderly):

• Two to five tablets (20mg to 50mg) as a single dose at night time

Use this medicine only as recommended. Do not exceed the recommended dose.

Exposure to sunlight

Phenergan Tablets can make your skin more sensitive to sunlight. Keep out of direct sunlight while taking this medicine.

If you take more Phenergan Tablets than you should

If you or your child takes more Phenergan Tablets than you should, tell a doctor or go to a hospital casualty department straight away. Take the medicine pack with you.

This is so the doctor knows what you or your child has taken.

The following effects may happen:

In children: Excitation, moving unsteadily or stumbling, uncontrolled writhing movements especially of the hands or feet, hallucinations, fits (seizures), loss of consciousness, uneven heart beat and breathing difficulties.

In adults: Feeling sleepy or drowsy, fits, loss of consciousness, uneven heart beat and breathing difficulties.

If you forget to take Phenergan Tablets Do not take a double dose to make up for a forgotten dose

• If you are taking Phenergan Tablets for an allergic condition – take your medicine as soon as you remember, then carry on as before
• If you are taking Phenergan Tablets for sedation or sleeping problems – miss that dose and take the next evening’s dose as usual

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Taking Phenergan Tablets may affect the results of certain tests. These include some pregnancy tests and skin tests. Phenergan Tablets should not be taken at least 3 days before the start of a skin test.

4. possible side effects

Like all medicines, Phenergan Tablets can cause side effects, although not everybody gets them.

• Stop taking Phenergan Tablets and see a doctor or go to a hospital straight away if you notice any of the following side effects: An allergic reaction. The signs may include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue
• Liver problems that may cause the eyes or skin to go yellow (jaundice)
• Muscle stiffness or shaking
• Being unable to control some muscles in your head or face
• You notice unusual movements of the tongue, facial muscle spasms, rolling eyes and trembling
• Very fast, uneven or forceful heartbeat (palpitations)
• Irregular heartbeat
• Tiredness which lasts for a long time. This may be due to a blood problem called anaemia
• Over-active behaviour in children

Tell your doctor or pharmacist if any of the following side effects get serious or lasts longer than a few days. Also tell them if you notice any side effects not listed in this leaflet.

• Dry mouth, blurred vision or you cannot pass water (urine)
• Feeling drowsy or sleepy, tiredness, disorientation, having nightmares, headaches, feeling restless
• Loss of appetite (anorexia), indigestion
• Feeling dizzy, lightheaded, faint (hypotension) Feeling confused, especially in elderly people Being more sensitive to the sun than usual.

If this happens keep out of direct sunlight and do not use sun lamps

• Unpleasant sensation or an overwhelming urge to move the legs (also called Restless Legs Syndrome).

Reporting of Side Effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at:. gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

By reporting side effects you can help provide more information on the safety of this medicine.

5. how to store phenergan tablets

• Keep this medicine out of the sight and reach of children
• Do not take Phenergan Tablets after the expiry date which is stated on the carton and blister pack after EXP. The expiry date refers to the last day of that month
• Store below 30°C
• Store in the original carton in order to protect from light

Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

6. contents of the pack and other information

What phenergan tablets contains..

• Each tablet contains 10mg of the active substance, promethazine hydrochloride
• The other ingredients are lactose, maize starch, povidone, magnesium stearate, polyethylene glycol, Opaspray (contains titanium dioxide-E171, hypromellose-E464 and indigo carmine aluminium lake blue-E132) and hypromellose

What Phenergan Tablets look like and contents of the pack

A pale blue film coated tablet marked PN 10 on one side. The tablets are available in blister packs of 56.

Marketing Authorisation Holder and Manufacturer

Marketing Authorisation Holder

410 Thames Valley Park Drive Reading

Tel: 0800 035 2525

Manufacturer

FAMAR HEALTH CARE SERVICES MADRID, S.A.U.

Avda. Leganes, 62

Alcorcon 28923

This leaflet does not contain all the information about your medicine. If you have any questions or are not sure about anything, ask your doctor or pharmacist.

This leaflet was last revised in 09/2020

© Sanofi, 2020